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| Open AccessA novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation
- Baijiao An
- , Wenyan Nie
- & Geng Tian
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Article
| Open AccessLZTR1 deficiency exerts high metastatic potential by enhancing sensitivity to EMT induction and controlling KLHL12-mediated collagen secretion
- Taiki Abe
- , Shin-ichiro Kanno
- & Yoko Aoki
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Article
| Open AccessNitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
- Laura Ryder
- , Frederic Schrøder Arendrup
- & Simon Bekker-Jensen
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Article
| Open AccessLRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner
- Elżbieta Kania
- , Jaclyn S. Long
- & Jan B. Parys
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Editorial
| Open AccessCyclin-dependent kinases regulate the adult nervous system via the one-carbon-metabolism
- Alessia Angelin
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Article
| Open AccessFBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2
- Rafael Jiménez-Izquierdo
- , Rosario Morrugares
- & Marco A. Calzado
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Article
| Open AccessThe hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression
Mitochondrial interaction of HKDC1 is essential for its pro-proliferative role in LC. When HKDC1 is ablated in liver cancer cells, mitochondrial dysfunction occurs which results in decrease ATP in the cells. The cancer cells react to decreased cellular energy by increasing glucose uptake. Also due to mitochondrial dysfunction there is enhanced ER stress and ER-mitochondrial interaction, leading to more calcium flux into the mitochondria. This multi-pronged effects of HKDC1 ablation leads to decreased cellular proliferation in LC.
- Md. Wasim Khan
- , Alexander R. Terry
- & Brian T. Layden
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Article
| Open AccessDeficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1
- Yonggang Zou
- , Qi Zheng
- & Hai Song
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Article
| Open AccessBimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons
- Elena R. Rhymes
- , Andrew P. Tosolini
- & Giampietro Schiavo
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Article
| Open AccessHuman RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
- Yanxiang Meng
- , Christopher R. Horne
- & James M. Murphy
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Article
| Open AccessMammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia
- Lei Sun
- , He Yang
- & Min Zhang
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Article
| Open AccessAnti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance
- Qincai Dong
- , Dapei Li
- & Xuan Liu
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Article
| Open AccessThe Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
- Annette V. Jacobsen
- , Catia L. Pierotti
- & James M. Murphy
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Article
| Open AccessNicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells
- Ya Meng
- , Chengcheng Song
- & Guokai Chen
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Article
| Open AccessCasein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease
- Barbara Bettegazzi
- , Laura Sebastian Monasor
- & Daniele Zacchetti
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Article
| Open AccessAntioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor
- Tom Delanghe
- , Jon Huyghe
- & Mathieu J. M. Bertrand
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Article
| Open AccessK63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR
- Pengshan Zhang
- , Zhe Zhang
- & Man Mohan
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Review Article
| Open AccessAutophagy as a modulator of cell death machinery
- Masayuki Noguchi
- , Noriyuki Hirata
- & John A. Chiorini
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Article
| Open AccessMKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer
- Lorenzo Stramucci
- , Angelina Pranteda
- & Gianluca Bossi
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Article
| Open AccessSPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells
- Jing Li
- , Na Li
- & Qianyu Zhuang
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Article
| Open AccessTargeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells
- Juanjuan Xiao
- , Fei Wang
- & Feng Zhu
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Article
| Open AccessThr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice
- Hyun-A. Seong
- & Hyunjung Ha
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Article
| Open AccessAutophagy-induced senescence is regulated by p38α signaling
- Konstantin Slobodnyuk
- , Nevenka Radic
- & Angel R. Nebreda
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Article
| Open AccessThe unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
- Mohamed Mahameed
- , Thomas Wilhelm
- & Boaz Tirosh
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Article
| Open AccessPIM kinases mediate resistance of glioblastoma cells to TRAIL by a p62/SQSTM1-dependent mechanism
- Santiago Serrano-Saenz
- , Carmen Palacios
- & F. Javier Oliver
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Article
| Open AccessNuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos
- Takuya Noguchi
- , Midori Suzuki
- & Atsushi Matsuzawa
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Original Article
| Open AccessCalcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration
- Luigi Racioppi
- , William Lento
- & Nelson Chao
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Original Article
| Open AccessThe role of MAP2 kinases and p38 kinase in acute murine liver injury models
- Jun Zhang
- , Robert W M Min
- & Neil Kaplowitz
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Original Article
| Open AccessEndogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis
- Kai Hu
- , Xianqiong Gong
- & Li Zhang
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Original Article
| Open AccessGRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal
- Qiumin Le
- , Wenqing Yao
- & Lan Ma
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Original Article
| Open AccessRIPK1 protects from TNF-α-mediated liver damage during hepatitis
- Aveline Filliol
- , Claire Piquet-Pellorce
- & Michel Samson
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Original Article
| Open AccessCDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis
- Kangmin Zhuang
- , Juchang Zhang
- & Side Liu
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Original Article
| Open AccessTAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints
- Xiaoyun Guo
- , Haifeng Yin
- & Qinghang Liu
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Original Article
| Open AccessKinase-independent function of RIP1, critical for mature T-cell survival and proliferation
- John P Dowling
- , Yubo Cai
- & Jianke Zhang
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Original Article
| Open AccessActivation of salt-inducible kinase 2 promotes the viability of peritoneal mesothelial cells exposed to stress of peritoneal dialysis
- H-H Wang
- , C-Y Lin
- & C-J Chang
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Original Article
| Open AccessMps1 kinase regulates tumor cell viability via its novel role in mitochondria
- X Zhang
- , Y Ling
- & R Z Ma
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Original Article
| Open AccessWee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy
- V Clausse
- , A R Goloudina
- & O N Demidov
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Original Article
| Open AccessLong non-coding RNA C2dat1 regulates CaMKIIδ expression to promote neuronal survival through the NF-κB signaling pathway following cerebral ischemia
- Q Xu
- , F Deng
- & A Ji
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Original Article
| Open AccessInhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α
- F Ren
- , L Zhang
- & Z Duan
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Original Article
| Open AccessNecroptosis in Niemann–Pick disease, type C1: a potential therapeutic target
- A Cougnoux
- , C Cluzeau
- & F D Porter
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News and Commentary
| Open AccessNGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
- P Ruggeri
- , L Cappabianca
- & A R Mackay
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Correspondence
| Open AccessLoss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2
- T Yuan
- , K D D Gorrepati
- & A Ardestani
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Original Article
| Open AccessGenetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype
- S Anzilotti
- , M Tornincasa
- & G M Pierantoni
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News and Commentary
| Open AccessDrilling into RIP1 biology: what compounds are in your toolkit?
- S B Berger
- , J Bertin
- & P J Gough
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Original Article
| Open AccessProtein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse
- M Peng
- , S M Ball-Kell
- & A L Tyner
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Original Article
| Open AccessLiver kinase B1 regulates the centrosome via PLK1
- K Werle
- , J Chen
- & Z-X Xu
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Original Article
| Open AccessA role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching
- A La Torre
- , M del Mar Masdeu
- & J M Ureña
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Original Article
| Open AccessPhosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death
- A M Brennan-Minnella
- , Y Shen
- & R A Swanson
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Original Article
| Open AccessA novel role for RIP1 kinase in mediating TNFα production
- D E Christofferson
- , Y Li
- & J Yuan