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| Open AccessNovel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer
- Qingyun Zhu
- , Qiuzi Dai
- & Yuyang Jiang
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Review Article
| Open AccessMechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases
- Lian Wang
- , Yanghui Zhu
- & Gu He
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Article
| Open AccessNew ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone
- Luciano de S. Santos
- , Valdenizia R. Silva
- & Daniel P. Bezerra
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Article
| Open AccessChlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2
- Claudia Abbruzzese
- , Silvia Matteoni
- & Marco G. Paggi
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Article
| Open AccessInhibition of PDGFRβ alleviates endothelial cell apoptotic injury caused by DRP-1 overexpression and mitochondria fusion failure after mitophagy
- Xiaohong An
- , Xiao Ma
- & Jia Zhou
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Review Article
| Open AccessIron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities
- Runyu Miao
- , Xinyi Fang
- & Jiaxing Tian
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Article
| Open AccessRg3 regulates myocardial pyruvate metabolism via P300-mediated dihydrolipoamide dehydrogenase 2-hydroxyisobutyrylation in TAC-induced cardiac hypertrophy
- Jingyu Ni
- , Hao Zhang
- & Guanwei Fan
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Article
| Open AccessInhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma
- Xiuqin Jia
- , Ming Xin
- & Jian Zhang
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Article
| Open AccessEllagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3
- Woo Yong Park
- , Gahee Song
- & Jae-Young Um
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Article
| Open AccessInhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy
- Di Xiao
- , Xin Hu
- & Xiaoping Yang
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Article
| Open AccessArtesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis
- Jingyi Zhang
- , Yuetong Wang
- & Yongkui Jing
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Article
| Open AccessFlubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer
- Yongqi Zhen
- , Zhaoxin Yuan
- & Xian-Li Zhou
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Article
| Open AccessThe anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression
- Yangyang Guo
- , Hengyue Zhu
- & Yongheng Bai
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Article
| Open AccessFDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair
- Shu-Ping Wang
- , Shi-Qi Wu
- & Yun-Gen Xu
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Article
| Open AccessActivation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner
- Guanyu Chen
- , Honghui Zeng
- & Bing Xue
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Article
| Open AccessApatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis
- Hui Yao
- , Jiangang Liu
- & Yulun Huang
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Review Article
| Open AccessThe critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
- Li Ning
- , Xiong Rui
- & Geng Qing
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Article
| Open AccessFosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex
- Scott J. Weir
- , Prasad Dandawate
- & Shrikant Anant
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Article
| Open AccessTherapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma
- Heng Yang
- , Yang Liu
- & Peng-Fei Tu
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Article
| Open AccessCephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer
- Asmat Ullah
- , Sze Wei Leong
- & Yanmin Zhang
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Article
| Open AccessFV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation
- Po Hu
- , Jubo Wang
- & Jingyan Xu
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Article
| Open AccessIsoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism
- Xiaozhong Huang
- , Yujuan Shi
- & Xiong Chen
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Article
| Open AccessAnti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf
- Yujia Xu
- , Tong Sun
- & Xinliang Mao
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Article
| Open Access(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis
- Min Wang
- , Chun-Yu Liu
- & Rong-Rong He
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Article
| Open AccessInhibition of the activation of γδT17 cells through PPARγ–PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid
- Xinming Yun
- , Yulai Fang
- & Yufeng Xia
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Article
| Open AccessTypically inhibiting USP14 promotes autophagy in M1-like macrophages and alleviates CLP-induced sepsis
- Fang Xu
- , Yuxiang Ma
- & Xudong Wu
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Article
| Open AccessTRPA1 mediates damage of the retina induced by ischemia and reperfusion in mice
- Daniel Souza Monteiro de Araújo
- , Francesco De Logu
- & Karin da Costa Calaza
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Article
| Open AccessTriggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1
- Minmin Fan
- , Jingwei Chen
- & Qiang Xu
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Article
| Open AccessHomoharringtonine suppresses tumor proliferation and migration by regulating EphB4-mediated β-catenin loss in hepatocellular carcinoma
- Man Zhu
- , Zhengyan Gong
- & Yanmin Zhang
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Article
| Open AccessNovel ginsenoside derivative 20(S)-Rh2E2 suppresses tumor growth and metastasis in vivo and in vitro via intervention of cancer cell energy metabolism
- Qi Huang
- , Hui Zhang
- & Vincent Kam Wai Wong
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Article
| Open AccessHederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells
- Kun Wang
- , Xiaodong Liu
- & Jianyong Xiao
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Article
| Open AccessRoseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells
- Xingqi Wang
- , Yuzhi Gao
- & Ruiqin Yao
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Article
| Open AccessGinsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway
- Xiangxiang Liu
- , Xiaojie Mi
- & Wei Li
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Article
| Open AccessTGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells
- Do Hyung Kim
- , Won Dong Kim
- & Seung Jin Lee
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Article
| Open AccessCaMKII/calpain interaction mediates ischemia/reperfusion injury in isolated rat hearts
- Hong-Ting Lu
- , Ren-Qian Feng
- & Jun Ren
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Article
| Open AccessIdentification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer
- Xueping Lei
- , Yihang Zhong
- & Xiyong Yu
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Article
| Open AccessAutophagy inhibition potentiates the anti-EMT effects of alteronol through TGF-β/Smad3 signaling in melanoma cells
- Yong Bao
- , Zhi Ding
- & Zhongming Qian
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Comment
| Open AccessReceptor-interacting protein 1 kinase inhibition therapeutically ameliorates experimental T cell-dependent colitis in mice
- Thomas Gobbetti
- , Scott B. Berger
- & Allison M. Beal
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Article
| Open AccessAnticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1
- Hai Zhang
- , Yu-ping Tan
- & Xiao-fei Shen
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Article
| Open AccessInhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
- Jian Gao
- , Shuang Peng
- & Yang Sun
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Article
| Open AccessSanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma
- Qi Su
- , Mengying Fan
- & Yanmin Zhang
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Article
| Open AccessFGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival
- Kailiang Zhou
- , Huanwen Chen
- & Huazi Xu
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Article
| Open AccessROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- Chuangyu Wen
- , Huihui Wang
- & Junsheng Peng
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Article
| Open AccessTargeting HDAC/OAZ1 axis with a novel inhibitor effectively reverses cisplatin resistance in non-small cell lung cancer
- Yuhong Sun
- , Xuefei Bao
- & Lihui Wang
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Article
| Open AccessSuppressing the Na+/H+ exchanger 1: a new sight to treat depression
- Xueyang Deng
- , Zhouye Ji
- & Shiping Ma
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Article
| Open Access3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression
- Jun Ni
- , Xiying Hou
- & Shougang Zhuang
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Article
| Open AccessBaicalein inhibits fibronectin-induced epithelial–mesenchymal transition by decreasing activation and upregulation of calpain-2
- Yan Chen
- , Lin Chen
- & Xiangchun Shen
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Article
| Open AccessTetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis
- Yugai Jia
- , Yu Tao
- & Yue Dai
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Article
| Open AccessSanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy
- Dan Hao
- , Xiang Wen
- & Xian Jiang