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| Open AccessDysfunctional autophagy induced by the pro-apoptotic natural compound climacostol in tumour cells
- Silvia Zecchini
- , Francesca Proietti Serafini
- & Davide Cervia
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Original Article
| Open AccessH19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses
- Jie Deng
- , Martin Mueller
- & Yingqun Huang
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Original Article
| Open AccessSoluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury
- Kishan Kapupara
- , Yao-Tseng Wen
- & Shun-Ping Huang
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Original Article
| Open AccessBortezomib-induced miRNAs direct epigenetic silencing of locus genes and trigger apoptosis in leukemia
- Yu-Yi Chu
- , Chiung-Yuan Ko
- & Ju-Ming Wang
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Original Article
| Open AccessA new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells
- Lin Zhao
- , Shengtang Liu
- & Ruhong Zhou
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Original Article
| Open AccessEpothilone B impairs functional recovery after spinal cord injury by increasing secretion of macrophage colony-stimulating factor
- Liang Mao
- , Wei Gao
- & Xifan Mei
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Original Article
| Open AccessDemethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells
- Yuzu Zhao
- , Jiang He
- & Hongjuan Cui
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Original Article
| Open Accessp53 dynamics orchestrates with binding affinity to target genes for cell fate decision
- Mengqiu Wu
- , Hui Ye
- & Haiping Hao
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Original Article
| Open AccessDCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway
- Xi Sun
- , Bo Li
- & Weiliang Zhu
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Original Article
| Open AccessTreatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage
- Raquel Boia
- , Filipe Elvas
- & Ana R Santiago
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Original Article
| Open AccessTrehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development
- Qian Tang
- , Gang Zheng
- & Haixiao Liu
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Original Article
| Open AccessHispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells
- Min-Chieh Hsin
- , Yi-Hsien Hsieh
- & Shun-Fa Yang
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Original Article
| Open AccessA novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells
- Wan Fu
- , Xue Li
- & Wei-Guo Zhu
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Original Article
| Open AccessBerberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition
- Dong Hou
- , Guangwei Xu
- & Changshun Shao
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Original Article
| Open AccessOveraccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells
- Sen Wang
- , Kexin Wang
- & Youquan Bu
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Original Article
| Open AccessCurcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt/β-catenin
- Zhaofeng Liang
- , Ling Lu
- & Wenrong Xu
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Original Article
| Open AccessBlocking autophagy enhances the apoptotic effect of 18β-glycyrrhetinic acid on human sarcoma cells via endoplasmic reticulum stress and JNK activation
- Shuying Shen
- , Menglu Zhou
- & Shunwu Fan
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Original Article
| Open AccessANGPTL4 mediates the protective role of PPARγ activators in the pathogenesis of preeclampsia
- Lei Liu
- , Xu Zhuang
- & Jianhua Lin
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Original Article
| Open AccessIdentification of 11(13)-dehydroivaxillin as a potent therapeutic agent against non-Hodgkin's lymphoma
- Xinhua Xiao
- , Huiliang Li
- & Yingli Wu
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Original Article
| Open AccessAmlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines
- Yang Liu
- , Jie Lu
- & Qiang Huang
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Original Article
| Open AccessCardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-κB pathway in nasopharyngeal carcinoma
- Yuting Li
- , You Qin
- & Gang Wu
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Original Article
| Open AccessHDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness
- Janina Leyk
- , Conor Daly
- & Christiane Richter-Landsberg
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Original Article
| Open AccessDoxorubicin upregulates CXCR4 via miR-200c/ZEB1-dependent mechanism in human cardiac mesenchymal progenitor cells
- Sara Beji
- , Giuseppina Milano
- & Elisa Gambini
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Original Article
| Open AccessTotal tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway
- Hongwei Gao
- , Xin Liu
- & Xiuping Chen
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Original Article
| Open AccessP53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment
- Rong-Jane Chen
- , Pei-Hsuan Wu
- & Ying-Jan Wang
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Original Article
| Open AccessThe triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy
- Dongwei Xu
- , Lili Chen
- & Xiaoni Kong
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Original Article
| Open AccessRETRACTED ARTICLE: Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β
- Xufeng Tao
- , Lina Xu
- & Jinyong Peng
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Original Article
| Open AccessAutophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens
- Álvaro F Fernández
- , Clea Bárcena
- & Guillermo Mariño
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Original Article
| Open AccessDi (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro
- Jing-Cai Liu
- , Fang-Nong Lai
- & Wei Shen
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Original Article
| Open AccessOroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression
- Libin Wei
- , Yuanyuan Dai
- & Lin Yang
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Original Article
| Open AccessProtection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction
- Yi Zhang
- , Xuehua Lv
- & Qinghuai Liu
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Original Article
| Open AccessEdaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma
- Kei Akaiwa
- , Kazuhiko Namekata
- & Takayuki Harada
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Original Article
| Open Accessp75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa
- María Platón-Corchado
- , Pablo F Barcelona
- & Enrique J de la Rosa
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Original Article
| Open AccessEpigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity
- Vikrant Borse
- , Raheem F H Al Aameri
- & Vickram Ramkumar
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Original Article
| Open AccessSorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury
- Sofie Martens
- , Manhyung Jeong
- & Peter Vandenabeele
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Original Article
| Open AccessInhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells
- Jiankang Wang
- , Bingling Luo
- & Shijun Wen
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Original Article
| Open AccessInteraction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis
- Zili Zhang
- , Zhen Yao
- & Shizhong Zheng
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Original Article
| Open AccessIsodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop
- Yang Wang
- , Jing Zhang
- & Qing-Yu He
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Original Article
| Open AccessRETRACTED ARTICLE:LISPRO mitigates β-amyloid and associated pathologies in Alzheimer’s mice
- Ahsan Habib
- , Darrell Sawmiller
- & Jun Tan
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Original Article
| Open AccessOroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism
- Ting Ni
- , Zihao He
- & Libin Wei
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Original Article
| Open AccessP7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo
- Chao Gu
- , Yan Zhang
- & Guanghui Wang
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Original Article
| Open AccessThe novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth
- Hyun Seung Ban
- , Bo-Kyung Kim
- & Misun Won
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Original Article
| Open AccessHIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination
- Mayilaadumveettil Nishana
- , Namrata M Nilavar
- & Sathees C Raghavan
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Original Article
| Open AccessDT-13 synergistically enhanced vinorelbine-mediated mitotic arrest through inhibition of FOXM1-BICD2 axis in non-small-cell lung cancer cells
- Hongyang Li
- , Li Sun
- & Sensen Lin
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Original Article
| Open AccessFuranodienone induces G0/G1 arrest and causes apoptosis via the ROS/MAPKs-mediated caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo
- Ying Jiang
- , Xiaoqin Wang
- & Daode Hu
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Original Article
| Open AccessAroclor1254 disrupts the blood–testis barrier by promoting endocytosis and degradation of junction proteins via p38 MAPK pathway
- Xiaoyu Jia
- , Ying Xu
- & Wenhui Su
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Original Article
| Open AccessBetulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism
- Xinxin Ci
- , Junfeng Zhou
- & Shucheng Hua
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Original Article
| Open AccessCycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme
- Lin Wang
- , Justin H Gundelach
- & Richard J Bram
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Original Article
| Open AccessNerve growth factor from Chinese cobra venom stimulates chondrogenic differentiation of mesenchymal stem cells
- Zhenhui Lu
- , Danqing Lei
- & Jinmin Zhao
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