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In this Review, Margolin and Cameron explore how the divisome of Escherichia coli is assembled and activated to modulate the division process, and discuss how the divisome machinery can be targeted for therapeutic purposes.
In this Review, Fishbein, Mahmud and Dantas discuss factors that influence restructuring of the gut microbiome on antibiotic exposure, and they explore promising therapeutic avenues aimed at minimizing antibiotic-induced damage to the microbiome or restoring the community structure post-treatment.
In this Review, Georjon and Bernheim provide an overview of the molecular diversity of the most recently discovered bacterial antiphage defence systems and discuss their evolution and the ecological impact of their diversity.
In this Review, Langedijk and Bont discuss our current understanding of respiratory syncytial virus (RSV) burden of disease, virus biology and pathogenesis, and host and viral factors related to immunity as a segue towards the development of novel RSV interventions.
In this Review, Castañeda-Barba, Top and Stalder use the One Health framework to synthesize the recent literature on the ecological and evolutionary factors that determine the successful local and global spread of plasmid-mediated antimicrobial resistance genes.
In this Review, Porter and Sullivan examine how Wolbachia interact with diverse host cellular components driving the endosymbiont’s global spread and discuss strategies to exploit Wolbachia for insect-based and parasite-based disease control.
In this Review, Xu, Gu and Lovley examine the varied mechanisms by which microorganisms can cause metal corrosion and explore different strategies that could prevent it.
In this Review, Landovitz, Scott and Deeks explore the current state of the art for HIV prevention and treatment, including unmet needs and emerging tools. They describe how researchers are combining different approaches, such as prevention, treatment and cure, to achieve better outcomes in the fight against the HIV/AIDS epidemic.
In this Review, Hsu and Schnabl examine the role of the gut microbiota in liver and intestine function, and how gut microorganisms contribute to liver diseases, and explore different microbiota-based strategies for the treatment of liver disease.
In this Review, Stride and co-workers discuss emerging drug delivery strategies that are explored in antibiofilm therapy to improve the clinical efficacy of antibiofilm agents, highlighting their current limitations and future prospects.
In this Review, Wang, Gao and Aksoy delve into the influence of microbiota on vector physiology and competence, provide an overview of the common and unique characteristics of microbiota in major disease vector systems and examine the potential applications of manipulating vector microbiota for vector control purposes.
In this Review, Martínez, Hernando-Amado and colleagues explore how eco-evolutionary-based approaches can aid in the design of successful antibiotic therapies, including the exploitation of evolutionary trade-offs, targeting bacterial metabolism and studying the ancestral functions of antibiotic resistance determinants.
In this Review, Carmody and Bisanz examine the role of the gut microbiome in energy metabolism, the two-way relationship between the gut microbiome and weight management strategies and opportunities and challenges in the development of microbiome-directed therapies targeting energy balance.
In this Review, Singh et al. explore the impact of future climate scenarios on plant pathogen burden and biogeography, their interaction with the plant microbiome and the consequences on plant disease and productivity in different ecosystems. They propose different approaches to ensure long-term global food security.
In this Review, Lemon and colleagues describe quasi-enveloped virions, how they enter and how they are released from the human host cell, and how they affect host immunity and pathogenesis.
In this Review, Smith, Foster and colleagues explore the protective strategies of bacteria, including the mechanisms, evolution and clinical implications of these ancient defences. They discuss new therapies for treating disease and how to minimize resistance evolution.
Over the course of the lifespan of a host, the gut microbiota undergoes evolutionary changes and is shaped by ecological interactions with the host and other microbial species. In this Review, Barreto and Gordo explore mechanisms of evolution of the gut microbiota, intrahost evolution of strains and communities and implications of intrahost evolution for disease and microbiota-based therapies.
In this Review, Markov, Katzourakis and colleagues explore the evolution of SARS-CoV-2 at different scales, the phases of the COVID-19 pandemic, factors that drive the evolution of the virus, theories for the emergence of epidemiologically important variants and potential future evolutionary scenarios and their likely health repercussions.
In this Review, Baldrian et al. discuss the effects of global change on the forest ecosystem and its microbiome across boreal, temperate and tropical climatic zones, and present different strategies aimed at reducing global change impact on forests.
In this Review, Toyofuku, Schild, Kaparakis-Liaskos and Eberl discuss the different types of bacterial membrane vesicle, how they are formed, their structure and composition and their diverse functions.
