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This study shows that hyphae formation is critical for Candida albicans gut colonization in the presence of commensal bacteria owing to the production of a hyphal-associated factor.
In this study, Armani-Tourret et al. show that the combination of panobinostat and pegylated interferon-α2a transforms the structure and composition of the HIV-1 reservoir and could potentially counter it.
In this study, Liu et al. explore the interplay between a fungal effector and a plant cysteine protease and design a small-molecule compound aimed at targeting this effector to combat rice blast disease.
In this Journal Club, Salvador Almagro-Moreno discusses a study by Kirn et al., which explores the emergence of virulence traits in Vibrio cholerae and demonstrates how the ability of this pathogen to colonize the host shares a common mechanism to its capacity to thrive in natural environments.
Wastewater genomic surveillance can transform global viral disease monitoring. This Genome Watch article explores the techniques, analytical pipelines and implications for public health.
In this Journal Club, Amelia Barber discusses a study revealing intraspecies heterogeneity in a fungal pathogen, prompting us to re-evaluate the notion of ‘reference’ strains.
In this study, Achberger et al. report that microbial communities of inactive hydrothermal deposits contribute to primary productivity in the deep sea.
This month’s Genome Watch discusses the application of spatial transcriptomics to investigate the arrangements of microbial communities and their effects on the host.
This study shows that the distinct cellular organization across the depth of a biofilm is tightly regulated and has consequences for cell physiology and antibiotic tolerance.
This study describes a signalling pathway involving the host receptor GPR35 and members of the gut microbiota, such as Parabacteroides distasonis, which regulates depressive-like behaviour.
This study reports that antibodies that target the fusion peptide on the HIV envelope provide protection to rhesus macaques against mucosal simian-HIV challenge.
This study describes Bdellovibrio bacteriovorus trimeric fibre proteins with diverse adhesive tips that enable the identification of a broad range of prey.
Two recent studies provide mechanistic understanding of how bacteria employ the Gabija system for defence against phages, as well as how phages use anti-defence proteins to overcome bacterial immunity.
In this study, Lee et al. analyse the structure and receptor-binding features of the spike glycoprotein from a clade 3 sarbecovirus to examine the risk of spillover from bats to humans.