Jennie Vallis

Role of phosphate sensing in bone and mineral metabolism

This Review discusses the metabolic effects of inorganic phosphate and the consequences of its dysregulation.

Latest Reviews

  • Review Article |

    Over the past 10 years, evidence has accumulated to suggest that α-cells are involved in the development of diabetes mellitus. This Review outlines our current understanding of α-cells and discusses how they could be targeted in the treatment of diabetes mellitus.

    • Jesper Gromada
    • , Pauline Chabosseau
    •  & Guy A. Rutter
  • Review Article |

    This Review focuses on the function of hypoxia-inducible factors (HIFs) in controlling metabolism and their influence in metabolic diseases (including obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease). The therapeutic potential of targeting HIFs for the treatment of metabolic diseases will also be discussed.

    • Frank J. Gonzalez
    • , Cen Xie
    •  & Changtao Jiang
  • Review Article |

    Inorganic phosphate (Pi) is a vital component of cellular metabolism and the extracellular matrix of the skeleton. In this Review, Sampada Chande and Clemens Bergwitz discuss the metabolic effects of Pi and the consequences of its dysregulation.

    • Sampada Chande
    •  & Clemens Bergwitz
  • Review Article |

    The WNT signalling pathway has been identified as a potential target for the development of therapeutics for osteoporosis. This Review discusses the specificity and potential off-target actions of WNT-based therapeutics and describes the available preclinical and clinical studies.

    • Natasha M. Appelman-Dijkstra
    •  & Socrates E. Papapoulos
  • Review Article |

    Circulating and imaging biomarkers could be useful for the diagnosis of neuroendocrine tumours (NETs). Here, Wouter de Herder and colleagues review the latest research on biomarkers in the NET field and provide clinicians with a comprehensive overview of relevant diagnostic biomarkers.

    • Johannes Hofland
    • , Wouter T. Zandee
    •  & Wouter W. de Herder

News & Comment

  • Comment |

    A male hormonal contraceptive would be a welcome addition to current family planning efforts. Herein, we summarize efforts to develop such a contraceptive, with a focus on contraceptive efficacy studies and new compounds that might offer advantages in terms of route of administration and longer half-lives compared with older compounds.

    • Stephanie T. Page
    •  & John K. Amory
  • News & Views |

    Pharmacotherapy for obesity, as an adjunct to targeted behavioural modifications, can facilitate weight loss. Previous serotonergic candidates have been withdrawn owing to undesirable cardiovascular effects. A new study in a large sample of high-risk patients shows lorcaserin treatment leads to no greater increase in cardiovascular problems than placebo — what does this result mean for personalized pharmacotherapy for obesity?

    • Carl A. Roberts
    •  & Jason C. G. Halford
  • News & Views |

    Transplanting pancreatic islets in immune-isolating capsules might cure type 1 diabetes mellitus while avoiding the immunosuppression that is normally needed to protect transplanted islets from rejection. A recent study demonstrates that allogeneic islets can survive in capsules with improved biocompatibility without immunosuppression in non-human primates, bringing us one step closer to applying this therapy in humans.

    • Tejal A. Desai
    •  & Qizhi Tang

Collection

Nobel Prize in Physiology or Medicine 2018

Springer Nature/The Nobel Foundation/Imagesource

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