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Volume 20 Issue 4, April 2024

How to manage iatrogenic adrenal insufficiency, inspired by the Review on p209.

Cover design: Jennie Vallis

Comment

  • The European Society of Endocrinology (ESE), representing 20,000 endocrinologists, is concerned about the effect of endocrine disrupting chemicals (EDCs) on endocrine health, particularly thyroid and gonadal function. The policy strategies of the ESE aim to minimize overall exposure of humans to EDCs and to stimulate funding for research at the level of the European Union.

    • Martin Reincke
    • Wiebke Arlt
    • Jerome Bertherat
    Comment

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  • Gonadotropin-releasing hormone is implicated in cognitive functions, and its loss is a factor in pathological brain ageing. There are similarities between these processes and the neurological and cognitive deficits observed in patients with long COVID. Here, we explore the hypothesis that neuroanatomical and transcriptomic alterations associated with long COVID could stem from this neuroendocrine perturbation.

    • S. Rasika
    • Ruben Nogueiras
    • Vincent Prevot
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Research Highlights

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Viewpoint

  • Organoid technologies are a potent tool for investigating human biology, modelling diseases and developing novel therapies. In this Viewpoint, experts in metabolic and endocrine research in the brain, pituitary, skeletal muscle, bone and gastrointestinal system discuss how organoids and related bioengineered systems are currently used in their field and how innovations in these technologies could transform future research.

    • Penney M. Gilbert
    • Sandra Hofmann
    • James M. Wells
    Viewpoint
  • Vitamin D is precursor of the steroid hormone calcitriol and has important functions throughout the body, including increasing intestinal absorption of calcium, magnesium and phosphate. Vitamin D deficiency has been linked with a range of disorders, including several bone diseases. However, large trials of vitamin D supplementation have produced mixed results. Here, experts from around the world discuss several key questions in the vitamin D research and clinical fields.

    • Andrea Giustina
    • Marise Lazaretti-Castro
    • Inez Schoenmakers
    Viewpoint
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Reviews

  • Iatrogenic adrenal insufficiency (IAI) is the most common form of adrenal insufficiency in adult patients. This comprehensive Review aims to aid clinicians in identifying who is at risk of IAI, how to approach screening of at-risk populations and how to treat patients with IAI.

    • Julie Martin-Grace
    • Maria Tomkins
    • Mark Sherlock
    Review Article
  • This Review describes a promising, bidirectional role for ghrelin in the interaction between circadian rhythms and metabolism. The authors explore how ghrelin affects outputs of circadian rhythm — including neuronal activity, circulating growth hormone levels, locomotor activity and eating behaviour — and discuss how circadian rhythms influence ghrelin expression.

    • Soumya S. Kulkarni
    • Omprakash Singh
    • Jeffrey M. Zigman
    Review Article
  • The protein complex mTORC1 is a key regulator of cellular metabolism in response to energy availability. This Review discusses the role of mTORC1 in regulating energy expenditure and the implications for the development and treatment of obesity.

    • Camille Allard
    • Cristina Miralpeix
    • Daniela Cota
    Review Article
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