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Conclusion In community-dwelling very elderly (≥80years) hypertensive patients, the baseline SBP showed a U-shaped curve relationship with the incident and development of long-term frailty, with the inflection points of the U-shaped curve being 135 mmHg and 140 mmHg, respectively, and the baseline PP level showed a U-shaped curve relationship with the development of long-term frailty, with the inflection point of 77 mmHg.
We investigated the association between SRBD and hypertension considering the effects of obesity, which would suggest the need to keep in mind the presence of SRBD even in non-obese individuals.
In an elderly Chinese population with previous and new-onset hypertension, we found that the new-onset hypertension during follow-up, compared with previous hypertension, was associated with a significantly higher risk of incident atrial fibrillation. In patients with previous hypertension, curvilinear association was observed between duration of hypertension and the risk of incident atrial fibrillation, with a higher risk in short- and long-term than mid-term duration of hypertension.
In spontaneously hypertensive rats, the combination of aerobic physical training with losartan treatment was crucial to greater blood pressure reductions and an increase in left ventricular contractility. Furthermore, losartan treatment prevented the concentric left ventricular remodeling caused by aerobic physical training.