Collection |

Technology for neuroengineering

Modelling and treating diseases of the central and peripheral nervous systems requires far better biomaterials and technology than are currently available.

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Research

News & Comment

Needle-sized photonic devices that slowly dissolve in the body can spectroscopically characterize cerebral temperature, blood oxygenation and neural activity for weeks in unconstrained mice.

News & Views | | Nature Biomedical Engineering

Smartphone-controlled optofluidic neural implants with replaceable and replenishable plug-like drug cartridges enable the selective wireless manipulation of brain circuits in rodents via chronic pharmacology and photostimulation.

News & Views | | Nature Biomedical Engineering

A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.

News & Views | | Nature Biomedical Engineering

Design principles for the development of silicon biointerfaces enable the non-genetic, light-controlled modulation of intracellular Ca2+ dynamics, and of cellular excitability in vitro, in tissue slices and in mouse brains.

News & Views | | Nature Biomedical Engineering

Polymer-coated gold nanoparticles carrying the CRISPR components for knocking out, in the striatum of adult mice with fragile X syndrome, a gene implied in the syndrome’s pathophysiology rescue the mice from the exaggerated repetitive behaviours characteristic of the syndrome’s phenotype.

News & Views | | Nature Biomedical Engineering