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Metabolism-disrupting chemicals (MDCs) are a subclass of endocrine-disrupting chemicals that affect energy homeostasis. Here, Angel Nadal and colleagues review the main mechanisms used by MDCs to alter energy balance, information that should help to identify new MDCs, as well as novel targets of their action.
This Review provides a framework for understanding how ambient temperature affects metabolic, immune and cardiovascular phenotypes in mice, as well as the importance of ambient temperature on modelling of human diseases in these small rodents. Ganeshan and Chawla suggest that warming the mouse might enable more predictive modelling of human diseases and therapies.
International guidelines recognize surgery as a standard treatment option for type 2 diabetes mellitus, including in mildly obese individuals who fail to respond to conventional therapies. A new report from the STAMPEDE trial now provides further evidence and emphasizes the need for health care regulators to introduce appropriate reimbursement policies for metabolic surgery.