Cancer articles within Nature

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  • Article |

    Induction of APOBEC3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that its suppression may represent a potential therapeutic strategy in the prevention of acquired resistance to lung cancer targeted therapy.

    • Hideko Isozaki
    • , Ramin Sakhtemani
    •  & Aaron N. Hata

  • News & Views |

    It turns out that commitment to cell division is not an irreversible switch. In the absence of sustained stimulation by growth factor proteins during DNA replication, cells can quit the cell cycle before cell division occurs.

    • Alexis R. Barr

  • Article |

    A study reports the development of an algorithm, BISCUT, that detects genomic loci under selective pressure by relying on the distribution of breakpoints across chromosome arms, and uses it to explore how aneuploidies affect tumorigenesis.

    • Juliann Shih
    • , Shahab Sarmashghi
    •  & Rameen Beroukhim

  • Article |

    Callosal projection neurons located in the hemisphere contralateral to primary glioblastoma promote progression and widespread infiltration, and screening of axon guidance genes identified SEMA4F as a key regulator of tumourigenesis and activity-dependent progression.

    • Emmet Huang-Hobbs
    • , Yi-Ting Cheng
    •  & Benjamin Deneen

  • Article |

    A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.

    • Jiexi Li
    • , Zhengdao Lan
    •  & Ronald A. DePinho

  • Research Briefing |

    The function of immune cells called B cells in cancer has been controversial. Single-cell profiling has identified a previously undescribed subset of B cells that express a protein called TIM-1 and that multiply in response to melanoma tumour growth. Deletion of the gene that encodes TIM-1 in these cells unleashed an antitumour immune response.

  • Article |

    Loss of the Y chromosome in tumour cells is associated with a poor prognosis for patients with bladder cancer by causing local T cell exhaustion, which also increases the response to immune checkpoint blockade therapy.

    • Hany A. Abdel-Hafiz
    • , Johanna M. Schafer
    •  & Dan Theodorescu

  • News & Views |

    Two studies now shed light on how chromosomes that undergo catastrophic shattering are transmitted to daughter cells during cell division, thereby enabling them to be reassembled for the benefit of cancer cells.

    • Yibo Xue
    •  & Daniel Durocher

  • Review Article |

    This Review examines the interplay between the nervous system and tumours, from cancer initiation to progression and metastasis.

    • Rebecca Mancusi
    •  & Michelle Monje

  • Article |

    Chromothriptically produced pieces of a micronucleated chromosome are shown to be tethered together in mitosis by a protein complex consisting of MDC1, TOPBP1 and CIP2A, thus enabling their inheritance by a single daughter cell.

    • Prasad Trivedi
    • , Christopher D. Steele
    •  & Don W. Cleveland

  • Article
    | Open Access

    This article describes a mechanism through which CD4+ T cells can eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting and thereby complement the activity of CD8+ T cells and natural killer cells to advance cancer immunotherapies.

    • Bastian Kruse
    • , Anthony C. Buzzai
    •  & Thomas Tüting

  • News & Views |

    Much remains to be discovered about how premalignant cells become cancer cells. An analysis of the development of a type of human leukaemia implicates ultraviolet light in triggering a rare form of cancer.

    • Elli Papaemmanuil

  • Article
    | Open Access

    Micronuclei, which are common features of nuclei in cancer cells, can generate heritable sources of transcriptional suppression, a finding that establishes an inherent relationship between chromosomal instability and variation in chromatin state and gene expression.

    • Stamatis Papathanasiou
    • , Nikos A. Mynhier
    •  & David Pellman

  • Article
    | Open Access

    Missegregated chromosomes that are sequestrated in micronuclei are subject to changes in histone modifications leading to abnormalities in chromatin accessibility that remain long after the chromosomes have been reincorporated into the primary nucleus.

    • Albert S. Agustinus
    • , Duaa Al-Rawi
    •  & Samuel F. Bakhoum

  • Article
    | Open Access

    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arises from clonal (premalignant) haematopoietic precursors in the bone marrow, and BPDCN skin tumours first develop at sun-exposed anatomical sites and are distinguished by clonally expanded mutations induced by ultraviolet radiation.

    • Gabriel K. Griffin
    • , Christopher A. G. Booth
    •  & Andrew A. Lane

  • News & Views |

    The compilation and analysis of a compendium of single-cell RNA-sequencing studies across various cancers reveals recurring gene-expression programs that underpin tumour heterogeneity.

    • Raymond W. S. Ng
    •  & Sydney M. Shaffer

  • Article
    | Open Access

    Skin tumour array by microporation (STAMP) captures the dynamic relationships of spatial, cellular and molecular components of tumour rejection and has the potential to translate therapeutic concepts into successful clinical strategies.

    • Guadalupe Ortiz-Muñoz
    • , Markus Brown
    •  & Christine Moussion

  • Article
    | Open Access

    A non-covalent inhibitor that binds preferentially to the inactive state of KRAS while sparing NRAS and HRAS is reported, indicating that most KRAS oncoproteins cycle between an active state and an inactive state in cancer cells.

    • Dongsung Kim
    • , Lorenz Herdeis
    •  & Piro Lito

  • Article |

    Remote tumours cause liver dysfunction by releasing extracellular vesicles and particles containing palmitic acid, which induces TNF signalling in Kupffer cells, resulting in inflammation, fatty deposits and metabolic dysregulation, thus both reducing the efficacy and increasing the toxicity of chemotherapies.

    • Gang Wang
    • , Jianlong Li
    •  & David Lyden

  • Article
    | Open Access

    An analysis of 780 breast cancer genomes shows that focal amplifications are frequently preceded by dicentric chromosome formation from inter-chromosomal translocations associated with oestrogen receptor binding, which leads to chromosome bridge formation and breakage, initiating the amplification process.

    • Jake June-Koo Lee
    • , Youngsook Lucy Jung
    •  & Peter J. Park

  • Article
    | Open Access

    A metabolite screen of pancreatic cells shows that pancreatic cancer cells metabolize uridine-derived ribose via UPP1, supporting redox balance, survival and proliferation.

    • Zeribe C. Nwosu
    • , Matthew H. Ward
    •  & Costas A. Lyssiotis

  • Article |

    Glioblastoma stem cells co-opt lysine uptake and degradation to shunt the production of crotonyl-CoA, remodelling the chromatin landscape to evade interferon-induced intrinsic effects on glioblastoma stem cell maintenance and extrinsic effects on immune response.

    • Huairui Yuan
    • , Xujia Wu
    •  & Jeremy N. Rich

  • News & Views |

    Efforts to tackle pancreatic cancer by harnessing immune cells have had limited success. A clinical trial reports promising results from testing a personalized approach to boosting immune responses to such tumours.

    • Amanda L. Huff
    •  & Neeha Zaidi

  • News & Views |

    Muscle loss during chronic disease is a life-threatening condition for which there is no effective treatment. The identification of an underlying molecular mechanism might offer new therapeutic targets.

    • Laura Antonio-Herrera
    •  & Andreas Bergthaler

  • Article
    | Open Access

    A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can induce T cell activity that may correlate with delayed recurrence of disease.

    • Luis A. Rojas
    • , Zachary Sethna
    •  & Vinod P. Balachandran

  • Article
    | Open Access

    This study illustrates long interspersed nuclear element-1 retrotransposition-induced somatic mosaicism in normal cells and provides insights into the genomic and epigenomic regulation of transposable elements over the human lifetime.

    • Chang Hyun Nam
    • , Jeonghwan Youk
    •  & Young Seok Ju

  • Article |

    Gene expression analysis in muscle tissues showed upregulation of ectodysplasin A2 receptor in tumour-bearing mice and patients with cachectic cancer, and thus therapeutic targeting of relevant pathways may be beneficial in prevention of muscle loss.

    • Sevval Nur Bilgic
    • , Aylin Domaniku
    •  & Serkan Kir

  • News & Views |

    Tumour cells can form connections with neurons in the brain. Examination of a variety of types of evidence concerning human brain cancer sheds light on how these tumour–neuron interactions affect cognition and survival times.

    • George M. Ibrahim
    •  & Michael D. Taylor

  • News & Views |

    A serendipitous observation has revealed that cells make several versions of a key protein needed for cell division. The ratio of these protein isoforms influences how long division can be delayed when errors arise.

    • Silke Hauf

  • Article |

    A mouse model of invasive breast cancer in which Pten and Trp53 are simultaneously inactivated links PTEN loss with STAT3 activation and indicates that immune escape in PTEN-null tumours is mediated by PI3Kβ.

    • Johann S. Bergholz
    • , Qiwei Wang
    •  & Jean J. Zhao

  • News & Views |

    Tumours with certain cancer-driving mutations are difficult to treat. A discovery that one enzyme both controls proliferation and suppresses anticancer immune defences presages the exploration of new cancer-therapy strategies.

    • Anghesom Ghebremedhin
    •  & Judith A. Varner

  • News & Views |

    The conversion of dietary sugar to the molecule lactate is a hallmark of many cancers. The discovery of a new binding partner of lactate provides insight into how cells link nutrient metabolism to the decision to divide.

    • Minervo Perez
    •  & Jordan L. Meier

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