Germ cell tumours articles within Nature

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• Letter | 30 November 2016

  Genomic evolution and chemoresistance in germ-cell tumours

  Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

  • Amaro Taylor-Weiner
  • , Travis Zack
  •  & Eliezer M Van Allen

• Letter | 04 June 2014

  Novel somatic and germline mutations in intracranial germ cell tumours

  Intracranial germ cell tumours are rare tumours affecting mainly male adolescents, mainly in Asia; here the authors identify frequent mutations in the KIT/RAS and AKT/mTOR signalling pathways as well as rare germline variants in JMJD1C, suggesting potential therapeutic strategies focusing on the inhibition of KIT/RAS activation and the AKT1/mTOR pathway.

  • Linghua Wang
  • , Shigeru Yamaguchi
  •  & Ching C. Lau