Head and neck cancer articles within Nature

Featured

• Article | 12 April 2023

  Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats

  Epstein–Barr Virus (EBV) nuclear antigen 1 is shown to induce breakage of a fragile site on chromosome 11 by binding to a cluster of EBV-like imperfect palindromic repeats.

  • Julia Su Zhou Li
  • , Ammal Abbasi
  •  & Don W. Cleveland

• Article | 30 November 2022

  Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer

  Defective DNA interstrand crosslink repair in Fanconi anaemia drives extensive genomic rearrangements, thereby substantially increasing the risk of cancer development.

  • Andrew L. H. Webster
  • , Mathijs A. Sanders
  •  & Agata Smogorzewska

• Article
  16 November 2022 | Open Access

  Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

  Spatial profiling and single-cell RNA sequencing are used to map the spatial distribution of the microbiota within human tumours, revealing how intratumoral microbial communities contribute to tumour heterogeneity and cancer progression.

  • Jorge Luis Galeano Niño
  • , Hanrui Wu
  •  & Susan Bullman

• Article
  29 June 2022 | Open Access

  Mitochondrial RNA modifications shape metabolic plasticity in metastasis

  • Sylvain Delaunay
  • , Gloria Pascual
  •  & Michaela Frye

• Article
  04 May 2022 | Open Access

  Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

  A study using a mouse solid tumour model suggests that adjusting the dosing frequency of the PI3Kδ inhibitor AMG319 in the treatment of human cancers could decrease tumour growth with fewer adverse effects.

  • Simon Eschweiler
  • , Ciro Ramírez-Suástegui
  •  & Christian H. Ottensmeier

• Article | 01 September 2021

  Functional HPV-specific PD-1⁺ stem-like CD8 T cells in head and neck cancer

  An analysis of human papillomavirus (HPV)-specific CD8 T cells in patients with head and neck cancer identifies functional PD-1⁺TCF-1⁺CD8 T cells in the tumour with implications for therapeutic vaccination and PD-1 directed immunotherapy.

  • Christiane S. Eberhardt
  • , Haydn T. Kissick
  •  & Rafi Ahmed

• Article | 18 November 2020

  Defining HPV-specific B cell responses in patients with head and neck cancer

  Detailed analyses of B cells in the tumour microenvironment of human papilloma virus (HPV)-linked head and neck cancers reveal strong humoral immune responses to HPV antigens and the secretion of HPV-specific antibodies in situ.

  • Andreas Wieland
  • , Mihir R. Patel
  •  & Rafi Ahmed

• Letter | 04 September 2019

  The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

  H3K36me2 targets DNMT3A to intergenic regions and this process, together with H3K36me3-mediated recruitment of DNMT3B, has a key role in establishing and maintaining genomic DNA methylation landscapes.

  • Daniel N. Weinberg
  • , Simon Papillon-Cavanagh
  •  & Chao Lu

• Article
  28 January 2015 | Open Access

  Comprehensive genomic characterization of head and neck squamous cell carcinomas

  The Cancer Genome Atlas presents an integrative genome-wide analysis of genetic alterations in 279 head and neck squamous cell carcinomas (HNSCCs), which are classified by human papillomavirus (HPV) status; alterations in EGFR, FGFR, PIK3CA and cyclin-dependent kinases are shown to represent candidate targets for therapeutic intervention in most HNSCCs.

  • Michael S. Lawrence
  • , Carrie Sougnez
  •  & Wendell G. Yarbrough

• Letter | 11 May 2014

  CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

  CFIm25 is identified as a factor that prevents messenger RNAs being shortened due to altered 3′ polyadenylation, which typically occurs when cells undergo high proliferation and correlates with increased tumorigenic activity in glioblastoma tumours.

  • Chioniso P. Masamha
  • , Zheng Xia
  •  & Eric J. Wagner

• Research Highlights | 02 February 2011

  Weakening tumour defences