Gastrointestinal cancer articles within Nature

Featured

  • Article
    | Open Access

    Topobiologically complex mini-colons—which enable the faithful in vitro recapitulation of colorectal cancer tumorigenesis and its environmental determinants—offer the possibility to reduce animal use in a wide range of experimental applications.

    • L. Francisco Lorenzo-Martín
    • , Tania Hübscher
    •  & Matthias P. Lutolf

  • Article
    | Open Access

    A study reveals that Fusobacterium nucleatum subspecies animalis is bifurcated into two distinct clades, and shows that only one of these dominates the colorectal cancer niche, probably through increased colonization of the human gastrointestinal tract.

    • Martha Zepeda-Rivera
    • , Samuel S. Minot
    •  & Christopher D. Johnston

  • Article |

    Transcriptomic and chromatin accessibility analyses of naive and transplanted colon cancer organoids in a mouse model reveal a key role for the transcription factor SOX17 in establishing a permissive immune environment for tumour cells.

    • Norihiro Goto
    • , Peter M. K. Westcott
    •  & Ömer H. Yilmaz

  • Article |

    The Chinese Liver Cancer Atlas project depicts a panoramic genomic landscape of hepatocellular carcinoma, covering candidate coding and non-coding drivers, mutational signatures, extrachromosomal circular DNA, subclonal catastrophic events and detailed evolutionary history.

    • Lei Chen
    • , Chong Zhang
    •  & Hongyang Wang

  • Article |

    Single-cell and spatial gene expression analyses of pancreatic ductal adenocarcinoma uncover a population of interleukin-1β-expressing macrophages that drive inflammatory reprogramming of neighboring tumour cells leading to disease progression and poor prognosis for patients.

    • Nicoletta Caronni
    • , Federica La Terza
    •  & Renato Ostuni

  • Article |

    A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.

    • Jiexi Li
    • , Zhengdao Lan
    •  & Ronald A. DePinho

  • Article |

    Remote tumours cause liver dysfunction by releasing extracellular vesicles and particles containing palmitic acid, which induces TNF signalling in Kupffer cells, resulting in inflammation, fatty deposits and metabolic dysregulation, thus both reducing the efficacy and increasing the toxicity of chemotherapies.

    • Gang Wang
    • , Jianlong Li
    •  & David Lyden

  • Article
    | Open Access

    A metabolite screen of pancreatic cells shows that pancreatic cancer cells metabolize uridine-derived ribose via UPP1, supporting redox balance, survival and proliferation.

    • Zeribe C. Nwosu
    • , Matthew H. Ward
    •  & Costas A. Lyssiotis

  • Article
    | Open Access

    A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can induce T cell activity that may correlate with delayed recurrence of disease.

    • Luis A. Rojas
    • , Zachary Sethna
    •  & Vinod P. Balachandran

  • Article
    | Open Access

    An analysis of whole-genome sequencing data from patients with Barrett’s oesophagus or oesophageal ademocarcinoma shows that extrachromosomal DNA (ecDNA) is strongly associated with cancer progression, and that a wide range of oncogenes are amplified on ecDNAs.

    • Jens Luebeck
    • , Alvin Wei Tian Ng
    •  & Paul S. Mischel

  • Article |

    Pancreatic ductal adenocarcinoma cells show a specific dependency on ornithine aminotransferase-mediated ornithine synthesis from glutamine, providing an opportunity to develop targeted therapies with minimal toxicity for this cancer.

    • Min-Sik Lee
    • , Courtney Dennis
    •  & Nada Y. Kalaany

  • Article
    | Open Access

    A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

    • Timon Heide
    • , Jacob Househam
    •  & Andrea Sottoriva

  • Article
    | Open Access

    Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.

    • Jacob Househam
    • , Timon Heide
    •  & Trevor A. Graham

  • Article |

    Subpopulations of cytokine-producing and myofibroblastic hepatic stellate cells, identified by single-cell RNA sequencing, protect against or promote the development of hepatocellular carcinoma via high expression of hepatocyte growth factor or type I collagen, respectively..

    • Aveline Filliol
    • , Yoshinobu Saito
    •  & Robert F. Schwabe

  • Article
    | Open Access

    Membrane-bound E3 ubiquitin ligases RNF43 and ZNRF3 are overexpressed in colorectal cancer, and can be repurposed using proteolysis-targeting antibodies (PROTABs) to selectively degrade cell-surface receptors in tumours.

    • Hadir Marei
    • , Wen-Ting K. Tsai
    •  & Felipe de Sousa e Melo

  • Article |

    A genetic lineage-tracing system in human colorectal organoids identifies a population of dormant cancer cells that persists during chemotherapy and enables cancer regrowth, and the cell-adhesion molecule COL17A1 has a key role in the process of breaking dormancy.

    • Yuki Ohta
    • , Masayuki Fujii
    •  & Toshiro Sato

  • Article |

    The growth of colorectal cancer is reduced by ketogenic diet consumption, the properties of which are mediated by the ketone body β-hydroxybutyrate.

    • Oxana Dmitrieva-Posocco
    • , Andrea C. Wong
    •  & Maayan Levy

  • Article
    | Open Access

    Results in the CheckMate 649 phase 3 trial for first-line combined nivolumab and chemotherapy treatment continue to show clinically meaningful efficacy in gastric, gastro-oesophageal junction or oesophageal adenocarcinoma after 24 months, with no new safety signals.

    • Kohei Shitara
    • , Jaffer A. Ajani
    •  & Yelena Y. Janjigian

  • Article
    | Open Access

    A survey of potency and efficacy of 2,025 clinically relevant two-drug combinations against 125 molecularly characterized breast, colorectal and pancreatic cancer cell lines identifies rare synergistic effects of anticancer drugs, informing rational combination treatments for specific cancer subtypes.

    • Patricia Jaaks
    • , Elizabeth A. Coker
    •  & Mathew J. Garnett

  • Article |

    A rare population of acinar cells expressing telomerase reverse transcriptase renew the acinar cell compartment during homeostasis, and are potential sources of premalignant cells in pancreatic carcinogenesis.

    • Patrick Neuhöfer
    • , Caitlin M. Roake
    •  & Steven E. Artandi

  • Article |

    In mouse models of pancreatic cancer, a cooperative interaction between tissue damage and Kras gene mutation rapidly induces cancer-associated chromatin states in pre-malignant tissue, leading to gene dysregulation and neoplastic transformation.

    • Direna Alonso-Curbelo
    • , Yu-Jui Ho
    •  & Scott W. Lowe

  • Review Article |

    This Review describes the interplay between host genetics, host immunity and the gut microbiome in the modulation of colorectal cancer, and discusses the role of specific bacterial species and metabolites alongside technological advances that will facilitate more in-depth investigation of the microbiome in disease.

    • Alina Janney
    • , Fiona Powrie
    •  & Elizabeth H. Mann

  • Article |

    Inhibition of the autophagy–lysosome system upregulates surface expression of MHC class I proteins and enhances antigen presentation, and evokes a potent anti-tumour immune response that is mediated by CD8+ T cells.

    • Keisuke Yamamoto
    • , Anthony Venida
    •  & Alec C. Kimmelman

  • Article |

    In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis.

    • Nobuyuki Kakiuchi
    • , Kenichi Yoshida
    •  & Seishi Ogawa

  • Article |

    Gastrointestinal stromal tumours can be initiated by gain-of-function mutations of the KIT or PDGFRA oncogenes but also by loss of the metabolic complex succinate dehydrogenase (SDH), which leads to DNA hypermethylation; this study shows that in SDH-deficient tumours, displacement of CTCF insulators by DNA methylation activates oncogene expression, illustrating how epigenetic alterations can drive oncogenic signalling in the absence of kinase mutations.

    • William A. Flavahan
    • , Yotam Drier
    •  & Bradley E. Bernstein

  • Letter |

    In an inducible mouse model of pancreatic ductal adenocarcinoma, the signalling defect that underlies 90% of these tumours causes increased cell-surface expression of syndecan 1, leading to misregulation of macropinocytosis, and linking the defective signalling with nutrient-salvage pathways.

    • Wantong Yao
    • , Johnathon L. Rose
    •  & Giulio F. Draetta

  • Letter |

    Sporadic inactivation of the interleukin-22 receptor in the intestinal epithelium of the mouse shows that IL-22 is required for effective activation of the DNA damage response following DNA damage.

    • Konrad Gronke
    • , Pedro P. Hernández
    •  & Andreas Diefenbach

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