Gynaecological cancer articles within Nature

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  • Article
    | Open Access

    We describe netrin-1 upregulation in a majority of human endometrial carcinomas and demonstrate that netrin-1 blockade, using the anti-netrin-1 antibody NP137, is effective both in a mouse model and in patients with endometrial carcinomas.

    • Philippe A. Cassier
    • , Raul Navaridas
    •  & Patrick Mehlen

  • Article
    | Open Access

    Single-cell whole-genome sequencing shows that 'foreground' cell-to-cell structural variation and alterations in copy number are associated with genomic diversity and evolution in triple-negative breast and high-grade serous ovarian cancers.

    • Tyler Funnell
    • , Ciara H. O’Flanagan
    •  & Samuel Aparicio

  • Article
    | Open Access

    In patients with high-grade serous ovarian cancer, robust and protective humoral responses are dominated by B-cell-derived polyclonal IgA that binds to polymeric IgA receptors that are universally expressed on ovarian cancer cells.

    • Subir Biswas
    • , Gunjan Mandal
    •  & Jose R. Conejo-Garcia

  • Article
    | Open Access

    This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.

    • Robert D. Burk
    • , Zigui Chen
    •  & David Mutch

  • Article |

    Whole-genome sequencing of tumour and germline DNA samples from 92 patients with high-grade serous ovarian cancer identifies frequent gene breakages that inactivate the tumour suppressors RB1, NF1, RAD51B and PTEN, and contribute to chemotherapy resistance; acquired resistance was associated with diverse mechanisms such as reversions of germline BRCA1/2 mutations and overexpression of the drug efflux pump MDR1.

    • Ann-Marie Patch
    • , Elizabeth L. Christie
    •  & David D. L. Bowtell

  • Letter |

    Whole-exome sequencing and analysis of 115 cervical carcinoma–normal paired samples, in addition to transcriptome and whole-genome sequencing for a subset of these tumours, reveal novel genes mutated at significant levels within this cohort and provide evidence that HPV integration is a common mechanism for target gene overexpression; results also compare mutational landscapes between squamous cell carcinomas and adenocarcinomas.

    • Akinyemi I. Ojesina
    • , Lee Lichtenstein
    •  & Matthew Meyerson

  • Letter |

    Interstrand crosslink (ICL) repair involves proteins whose mutation results in the disorder Fanconi anaemia: here gene knockdown studies in mice show that the absence of HELQ, a protein previously implicated in ICL repair, compromises germ cell development and results in tumour predisposition due to defective recombination at damaged replication forks.

    • Carrie A. Adelman
    • , Rafal L. Lolo
    •  & Simon J. Boulton

  • Article
    | Open Access

    An integrative genomic analysis of several hundred endometrial carcinomas shows that a minority of tumour samples carry copy number alterations or TP53 mutations and many contain key cancer-related gene mutations, such as those involved in canonical pathways and chromatin remodelling; a reclassification of endometrial tumours into four distinct types is proposed, which may have an effect on patient treatment regimes.

    • Douglas A. Levine
    • , Gad Getz
    •  & Douglas A. Levine

  • Letter |

    The hilum (a transitional region) of the mouse ovary is identified as a stem cell niche of the ovarian surface epithelium, and its cells are prone to malignant transformation after inactivation of common tumour suppressor genes, suggesting that they may be the origin of ovarian carcinoma.

    • Andrea Flesken-Nikitin
    • , Chang-Il Hwang
    •  & Alexander Yu. Nikitin

  • Letter |

    Rare truncating mutations in the p53-inducible protein phosphatase PPM1D are shown to be associated with predisposition to breast cancer and ovarian cancer; notably, all of the mutations are mosaic in white blood cells but are not present in tumours, and probably have a gain-of-function effect.

    • Elise Ruark
    • , Katie Snape
    •  & Nazneen Rahman

  • Outlook |

    Human papillomavirus (HPV) has become synonymous with cervical cancer, but its actual footprint is much bigger, by James Mitchell Crow.

    • James Mitchell Crow

  • Outlook |

    Pap tests have been a mainstay of cervical cancer screening, but new tests, vaccines and knowledge might be changing that, including when and how frequently to test.

    • Courtney Humphries

  • Outlook |

    Two vaccines seem to be so effective in preventing HPV infection that mass vaccination has been introduced for girls. But will long-term studies show falls in cervical cancer?

    • Julie Clayton

  • Outlook |

    Linking specific types of HPV with cervical cancer and developing effective vaccines against should be celebrated. But there are gaps in our understanding of these viruses and how they cause disease.

    • Laura Vargas-Parada

  • Outlook |

    A Nobel prizewinner for pinning cervical cancer on human papillomavirus, Harald zur Hausen still investigates viruses. Nature Outlook talks to the medical doctor–turned–virologist about other possible culprits.

    • Harald zur Hausen

  • Outlook |

    Vaccines on the market aren't practical for the developing world — where cervical cancer hits hardest — but researchers are trying to make ones that are.

    • Katharine Sanderson

  • Outlook |

    HPV-associated cancers in men are on the rise. By not vaccinating boys we are failing to gain maximum health benefit, argues Margaret Stanley.

    • Margaret Stanley

  • Outlook |

    Sub-Saharan countries lag behind in screening and treatment for human papillomavirus. But national efforts and the introduction of low-tech methods could change that.

    • Michael Eisenstein

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