Tumour biomarkers articles within Nature

Featured

  • Article
    | Open Access

    Imaging mass cytometry is used to map the multicellular dynamics of immune checkpoint blockade-treated triple-negative breast cancer, finding that key proliferative fractions and cell–cell interactions drive response, and immunotherapy distinctively remodels tumour structure.

    • Xiao Qian Wang
    • , Esther Danenberg
    •  & H. Raza Ali

  • Perspective |

    This Perspective reviews the utility and interpretation of circulating tumour DNA for the detection of residual and recurrent cancers and provides recommendations regarding its clinical application for a variety of solid tumours.

    • Stacey A. Cohen
    • , Minetta C. Liu
    •  & Alexey Aleshin

  • Article |

    Multi-omic mapping shows that group 3 and group 4 medulloblastomas have a common, human-specific developmental origin in the cerebellar rhombic lip, providing a basis for their ambiguous molecular features and overlapping anatomical location, and for the difficulty of modelling these tumours in mice.

    • Kyle S. Smith
    • , Laure Bihannic
    •  & Paul A. Northcott

  • Article |

    Deep whole-genome sequencing of serial blood samples and matched metastatic tissue reveals that circulating tumour DNA profiling enables detailed study of treatment-driven subclone dynamics, epigenomics and genome-wide somatic evolution in metastatic human cancers.

    • Cameron Herberts
    • , Matti Annala
    •  & Alexander W. Wyatt

  • Letter |

    Analysis of more than 17,000 tumours suggests that the contribution of germline and somatic mutations in the BRCA1 and BRCA2 genes to oncogenesis depends on tumour lineage.

    • Philip Jonsson
    • , Chaitanya Bandlamudi
    •  & Barry S. Taylor

  • Letter |

    Analyses of fragmentation patterns of cell-free DNA in the blood of patients with cancer and healthy individuals using a machine learning algorithm provide a proof-of principle approach for the early detection and screening of human cancer.

    • Stephen Cristiano
    • , Alessandro Leal
    •  & Victor E. Velculescu

  • Letter |

    In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

    • Sanjeev Mariathasan
    • , Shannon J. Turley
    •  & Thomas Powles

  • Letter |

    A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy response and survival, facilitating initial treatment stratification.

    • Stanley W. K. Ng
    • , Amanda Mitchell
    •  & Jean C. Y. Wang

  • Analysis |

    This Analysis compares two large-scale pharmacogenomic data sets that catalogued the sensitivity of a large number of cancer cell lines to approved and potential drugs, and finds that whereas the gene expression data are largely concordant between the two studies, the reported drug sensitivity measures and subsequently their association with genomic features are highly discordant.

    • Benjamin Haibe-Kains
    • , Nehme El-Hachem
    •  & John Quackenbush

  • Outlook |

    Identifying the patients most likely to progress from a precancerous condition to multiple myeloma could help doctors catch the disease early and stop it taking hold.

    • Lauren Gravitz

  • Outlook |

    Being able to determine an individual's chances of developing cancer will greatly improve risk management strategies and recruitment to clinical trials.

    • Vicki Brower

  • News & Views |

    Tumour cells are non-uniform. The question is whether a distinct subpopulation of the cells drives tumour growth and generates cellular variation. To answer this, the data must be interpreted carefully.

    • Peter Dirks

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