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CD4+ T Cell Diversity

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CD4+ T helper cells are crucial for orchestrating the adaptive immune response by recruiting and activating other cells of the immune system. Traditionally, CD4+ T helper cells were classified as either TH1 or TH2 cells based on cytokine secretion, signaling pathways and lineage-specific transcription factors. More recently, more CD4+ T cell subsets have been identified, including TH9, TH17 and Treg cells. Rather than being terminally differentiated, these heterogenous T cell subsets seem highly plastic. This collection of articles highlights seminal research in the area of CD4+ T cell diversity and plasticity.

The collection is free thanks to support from BD Biosciences.

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CD4+ T Cell Diversity Collection

Article

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot JD, Gavin MA, Rudensky AY

Nature Immunology 4(4):330-6 (2003)

doi:10.1038/ni904

Abstract |  Full Text | PDF

Article

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA

Nature Immunology 10(9):1000-7 (2009)

doi:10.1038/ni.1774

Abstract | Full Text | PDF

Article

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset

Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, Martin B, Wilhelm C, Stockinger B

Nature Immunology 9(12):1341-6 (2008)

doi:10.1038/ni.1659

Abstract |  Full Text | PDF

Article

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A, Lanzavecchia A, Engelhardt B, Sallusto F

Nature Immunology 10(5):514-23 (2009)

doi:10.1038/ni.1716

Abstract |  Full Text | PDF

Article

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H

Nature Immunology 10(8):864-71 (2009)

doi:10.1038/ni.1770

Abstract |  Full Text | PDF

Article

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.

Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK

Nature Immunology 10(2):167-75 (2009)

doi:10.1038/ni.1690

Abstract | Full Text | PDF

Article

Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells

Rudra D, Egawa T, Chong MM, Treuting P, Littman DR, Rudensky AY

Nature Immunology 10(11):1170-7 (2009)

doi:10.1038/ni.1795

Abstract | Full Text | PDF

Article

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10

Maynard CL, Harrington LE, Janowski KM, Oliver JR, Zindl CL, Rudensky AY, Weaver CT

Nature Immunology 8(9):931-41 (2007)

doi:10.1038/ni1504

Abstract | Full Text | PDF

Article

Cytokine-secreting follicular T cells shape the antibody repertoire

Reinhardt RL, Liang HE, Locksley RM

Nature Immunology 10(4):385-93 (2009)

doi:10.1038/ni.1715

Abstract | Full Text | PDF

Article

Regulation of IL-9 expression by IL-25 signaling

Angkasekwinai P, Chang SH, Thapa M, Watarai H, Dong C

Nature Immunology 11(3):250-6 (2010)

doi:10.1038/ni.1846

Abstract | Full Text | PDF

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