Article abstract
Nature Immunology 10, 167 - 175 (2008)
Published online: 21 December 2008 | doi:10.1038/ni.1690
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
Aurelie T Bauquet1, Hulin Jin1,4, Alison M Paterson2,4, Meike Mitsdoerffer1, I-Cheng Ho3, Arlene H Sharpe2 & Vijay K Kuchroo1
Abstract
The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (TH-17 cells) and of follicular helper T cells (TFH cells). Here we show that ICOS-deficient mice had no defect in TH-17 differentiation but had fewer TH-17 cells after IL-23 stimulation and fewer TFH cells. We also show that TFH cells produced IL-17 and that TFH cells in ICOS-deficient mice were defective in IL-17 production. Both TH-17 and TFH cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer TH-17 and TFH cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of TH-17 and TFH cells.
- Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
- Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
- Division of Rheumatology, Immunology and Allergy and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
- These authors contributed equally to this work.
Correspondence to: Vijay K Kuchroo1 e-mail: vkuchroo@rics.bwh.harvard.edu
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