TAL effector nucleases collection
TAL Effector Nucleases
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Sponsor's Foreword
A disruptive technology is defined as a technological innovation that creates a paradigm shift in markets and consumers' lives. Twenty years from now, which life science breakthroughs will be looked back as disruptive technologies?
We believe that the capacity to customize genomes at will is such a breakthrough. We believe that generating application-driven cells and organisms with novel characteristics and user-defined performance will drive the next decades in biology. We believe that Transcription Activator Like Effector Nucleases (TALEN®) carry the promise of our company, Cellectis bioresearch, to bring to your bench customized cells and affordable research tools to generate them.
TALENs have the potential to unleash the creativity of bench biologists around the world, and the following scientific publications demonstrate that while recent, this novel technology has matured very rapidly. Cellectis bioresearch has made TALENs cost-effective through its exclusive TALEN® Access offer, and has developed TALENs as a genome-wide tool by increasing production capacity to 7,200 units per year.
Disruptive technologies must be efficient, robust, universally adoptable and scalable: any gene, any position for whole genomes and for everyone. No limit, just talent.
The complete digital edition can be accessed here.
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Sponsor Feature
Cellectis bioresearch
Sponsor advertisement
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Introduction
TAL effector nucleases
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News Feature
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Correspondence
Knockout rats generated by embryo microinjection of TALENs
Laurent Tesson, Claire Usal, Séverine Ménoret, Elo Leung, Brett J Niles, Séverine Remy, Yolanda Santiago, Anna I Vincent, Xiangdong Meng, Lei Zhang, Philip D Gregory, Ignacio Anegon & Gregory J Cost
Nature Biotechnology 29, 695–696 (2011)
doi:10.1038/nbt.1940
Targeted gene disruption in somatic zebrafish cells using engineered TALENs
Jeffry D Sander, Lindsay Cade, Cyd Khayter, Deepak Reyon, Randall T Peterson, J Keith Joung & Jing-Ruey J Yeh
Nature Biotechnology 29, 697–698 (2011)
doi:10.1038/nbt.1934
Heritable gene targeting in zebrafish using customized TALENs
Peng Huang, An Xiao, Mingguo Zhou, Zuoyan Zhu, Shuo Lin & Bo Zhang
Nature Biotechnology 29, 699–700 (2011)
doi:10.1038/nbt.1939
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Brief communication
Genetic engineering of human pluripotent cells using TALE nucleases
Dirk Hockemeyer, Haoyi Wang, Samira Kiani, Christine S Lai, Qing Gao, John P Cassady, Gregory J Cost, Lei Zhang, Yolanda Santiago, Jeffrey C Miller, Bryan Zeitler, Jennifer M Cherone, Xiangdong Meng, Sarah J Hinkley, Edward J Rebar, Philip D Gregory, Fyodor D Urnov & Rudolf Jaenisch
Nature Biotechnology 29, 731–734 (2011)
doi:10.1038/nbt.1927
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Article
A TALE nuclease architecture for efficient genome editing
Jeffrey C Miller, Siyuan Tan, Guijuan Qiao, Kyle A Barlow, Jianbin Wang, Danny F Xia, Xiangdong Meng, David E Paschon, Elo Leung, Sarah J Hinkley, Gladys P Dulay, Kevin L Hua, Irina Ankoudinova, Gregory J Cost, Fyodor D Urnov, H Steve Zhang, Michael C Holmes, Lei Zhang, Philip D Gregory & Edward J Rebar
Nature Biotechnology 29, 143–148 (2011)
doi:10.1038/nbt.1755
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