Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch." Their research identified transient receptor potential (TRP) and PIEZO ion channels as the proteins that sense these ubiquitous stimuli. To celebrate the award Nature Portfolio presents a Collection including publications from the winners, essential reviews on the topic, and further exciting research focused on different aspects of TRP and PIEZO channels and their roles in physiology and disease