The hippocampus as a predictive map

Latest Research

  • Article |

    The critical period of ocular dominance (OD) plasticity in the visual cortex is initiated by maturation of inhibition. The authors show that thalamic relay neurons in mouse dorsolateral geniculate nucleus also undergo OD plasticity. This process depends on thalamic inhibition and is required for consolidating the OD shift in visual cortex.

    • Jean-Pierre Sommeijer
    • , Mehran Ahmadlou
    • , M. Hadi Saiepour
    • , Koen Seignette
    • , Rogier Min
    • , J. Alexander Heimel
    •  & Christiaan N. Levelt
  • Article |

    Animals must detect noxious stimuli to initiate protective behavior, but the evolutionary origin of nociceptive systems is poorly understood. The authors reveal a core function for TRPA1 in noxious heat transduction based on sensing H2O2 and ROS and demonstrate its conservation from planarians to humans.

    • Oscar M. Arenas
    • , Emanuela E. Zaharieva
    • , Alessia Para
    • , Constanza Vásquez-Doorman
    • , Christian P. Petersen
    •  & Marco Gallio
  • Article |

    Neurons in the lateral prefrontal cortex (but not the frontal eye fields) appear to maintain working memory information when disrupted by a transient distractor, not by using an immutable persistent code but by morphing from one persistent code to another. This code-morphing may provide the lateral prefrontal cortex with cognitive flexibility.

    • Aishwarya Parthasarathy
    • , Roger Herikstad
    • , Jit Hon Bong
    • , Felipe Salvador Medina
    • , Camilo Libedinsky
    •  & Shih-Cheng Yen
  • Article |

    Davis et al. report that fear memories can be critically regulated by parvalbumin-expressing interneurons in the basolateral amygdala. Silencing these interneurons following fear memory extinction caused a reemergence of fear expression that was accompanied by increased activation of fear-encoding neurons and fear-associated 3–6 Hz oscillations within a basolateral amygdala–prefrontal cortex circuit.

    • Patrick Davis
    • , Yosif Zaki
    • , Jamie Maguire
    •  & Leon G Reijmers
  • Article |

    The authors show how predictive representations are useful for maximizing future reward, particularly in spatial domains. They develop a predictive-map model of hippocampal place cells and entorhinal grid cells that captures a wide variety of effects from human and rodent literature.

    • Kimberly L Stachenfeld
    • , Matthew M Botvinick
    •  & Samuel J Gershman

News & Comment

  • News and Views |

    Central amygdala directs behavioral responses to emotionally salient stimuli. While most studies have focused on aversive responses, some central amygdala neurons promote feeding and are positively reinforcing.

    • Yoav Livneh
    •  & Mark L Andermann
  • News and Views |

    Upon injury of the developing mouse cerebellum, endogenous repair mechanisms can heal the brain and prevent behavioral motor deficits. At the right time, with the right cues, the brain can repair itself.

    • Baptiste N Jaeger
    •  & Sebastian Jessberger
  • News and Views |

    Inputs to the central complex, the navigation center of Drosophila, are strongly modulated by the visual stimulus history. These history effects carry forward to bias turning behavior when flies choose between two visual stimuli.

    • Mai M Morimoto
    •  & Aman B Saleem
  • News and Views |

    What is the basis for the feeling that someplace or someone is familiar? Molas et al. have identified brain structures involved in signaling familiarity, a necessary element for the expression of preference for novelty.

    • Rebecca D Burwell
    •  & Victoria L Templer
  • News and Views |

    Zika virus infection is associated with birth defects, including microcephaly, but also with disorders of peripheral nerves. Oh et al. use rodent and human cell models to explore how the virus affects the peripheral nervous system.

    • Themasap A. Khan
    •  & Sergiu P. Paşca

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