Hypothalamic control of female aggression

Latest Research

  • Article |

    The mechanisms of gliotransmitter release and their impact on neuronal signaling have remained largely elusive. The authors describe two functionally non-overlapping v-SNARE-dependent astrocytic release pathways that oppositely control synaptic strength at presynaptic sites. Thus, astrocytes are able to fine-tune fast glutamatergic neurotransmission and control fundamental processes of synaptic communication.

    • Yvonne Schwarz
    • , Na Zhao
    • , Frank Kirchhoff
    •  & Dieter Bruns
  • Article |

    Astrocytes differentially regulate excitatory and inhibitory synaptic transmission in the CeM, the major output nucleus of the amygdala. Astrocytes thereby reduce neuronal activity in the CeM and diminish fear expression in vivo. Therefore, astrocytes influence neural network activity and animal behavior through the regulation of specific synapses.

    • Mario Martin-Fernandez
    • , Stephanie Jamison
    • , Laurie M Robin
    • , Zhe Zhao
    • , Eduardo D Martin
    • , Juan Aguilar
    • , Michael A Benneyworth
    • , Giovanni Marsicano
    •  & Alfonso Araque
  • Article |

    The precise underpinnings of Parkinson's disease and other disorders associated with the accumulation of α-synuclein are unclear. This study shows that PrPC mediates α-synuclein-associated synaptic dysfunction and memory deficits. Blocking specific events in receptor biology rescued cognitive deficits in mice, suggesting new possibilities for intervention in synucleinopathies.

    • Diana G Ferreira
    • , Mariana Temido-Ferreira
    • , Hugo Vicente Miranda
    • , Vânia L Batalha
    • , Joana E Coelho
    • , Éva M Szegö
    • , Inês Marques-Morgado
    • , Sandra H Vaz
    • , Jeong Seop Rhee
    • , Matthias Schmitz
    • , Inga Zerr
    • , Luísa V Lopes
    •  & Tiago F Outeiro

News & Comment

  • News and Views |

    Central amygdala directs behavioral responses to emotionally salient stimuli. While most studies have focused on aversive responses, some central amygdala neurons promote feeding and are positively reinforcing.

    • Yoav Livneh
    •  & Mark L Andermann
  • News and Views |

    Upon injury of the developing mouse cerebellum, endogenous repair mechanisms can heal the brain and prevent behavioral motor deficits. At the right time, with the right cues, the brain can repair itself.

    • Baptiste N Jaeger
    •  & Sebastian Jessberger
  • News and Views |

    Inputs to the central complex, the navigation center of Drosophila, are strongly modulated by the visual stimulus history. These history effects carry forward to bias turning behavior when flies choose between two visual stimuli.

    • Mai M Morimoto
    •  & Aman B Saleem
  • News and Views |

    What is the basis for the feeling that someplace or someone is familiar? Molas et al. have identified brain structures involved in signaling familiarity, a necessary element for the expression of preference for novelty.

    • Rebecca D Burwell
    •  & Victoria L Templer
  • News and Views |

    Zika virus infection is associated with birth defects, including microcephaly, but also with disorders of peripheral nerves. Oh et al. use rodent and human cell models to explore how the virus affects the peripheral nervous system.

    • Themasap A. Khan
    •  & Sergiu P. Paşca

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