Hypothalamic control of female aggression

Latest Research

  • Article |

    The mechanisms of gliotransmitter release and their impact on neuronal signaling have remained largely elusive. The authors describe two functionally non-overlapping v-SNARE-dependent astrocytic release pathways that oppositely control synaptic strength at presynaptic sites. Thus, astrocytes are able to fine-tune fast glutamatergic neurotransmission and control fundamental processes of synaptic communication.

    • Yvonne Schwarz
    • , Na Zhao
    • , Frank Kirchhoff
    •  & Dieter Bruns
  • Article |

    Astrocytes differentially regulate excitatory and inhibitory synaptic transmission in the CeM, the major output nucleus of the amygdala. Astrocytes thereby reduce neuronal activity in the CeM and diminish fear expression in vivo. Therefore, astrocytes influence neural network activity and animal behavior through the regulation of specific synapses.

    • Mario Martin-Fernandez
    • , Stephanie Jamison
    • , Laurie M Robin
    • , Zhe Zhao
    • , Eduardo D Martin
    • , Juan Aguilar
    • , Michael A Benneyworth
    • , Giovanni Marsicano
    •  & Alfonso Araque
  • Article |

    The precise underpinnings of Parkinson's disease and other disorders associated with the accumulation of α-synuclein are unclear. This study shows that PrPC mediates α-synuclein-associated synaptic dysfunction and memory deficits. Blocking specific events in receptor biology rescued cognitive deficits in mice, suggesting new possibilities for intervention in synucleinopathies.

    • Diana G Ferreira
    • , Mariana Temido-Ferreira
    • , Hugo Vicente Miranda
    • , Vânia L Batalha
    • , Joana E Coelho
    • , Éva M Szegö
    • , Inês Marques-Morgado
    • , Sandra H Vaz
    • , Jeong Seop Rhee
    • , Matthias Schmitz
    • , Inga Zerr
    • , Luísa V Lopes
    •  & Tiago F Outeiro
  • Article |

    Spinal cord injury causes life-threatening infections. The authors report that this is partially mediated by a maladaptive neuroendocrine reflex extending from the spinal cord to the adrenal glands, where it blocks catecholamines while producing immunosuppressive corticosteroids. The effect depends on the spinal injury level, and normalization of hormones production by the adrenals rescues mice from pneumonia.

    • Harald Prüss
    • , Andrea Tedeschi
    • , Aude Thiriot
    • , Lydia Lynch
    • , Scott M Loughhead
    • , Susanne Stutte
    • , Irina B Mazo
    • , Marcel A Kopp
    • , Benedikt Brommer
    • , Christian Blex
    • , Laura-Christin Geurtz
    • , Thomas Liebscher
    • , Andreas Niedeggen
    • , Ulrich Dirnagl
    • , Frank Bradke
    • , Magdalena S Volz
    • , Michael J DeVivo
    • , Yuying Chen
    • , Ulrich H von Andrian
    •  & Jan M Schwab
  • Article |

    The authors identify the midcingulate cortex as a region that gates nociceptive plasticity without modulating basal nociception or the affective component of acute pain in mice. They identify a novel pathway from the midcingulate cortex to the posterior insula that recruits descending serotonergic projections to facilitate nociception.

    • Linette Liqi Tan
    • , Patric Pelzer
    • , Céline Heinl
    • , Wannan Tang
    • , Vijayan Gangadharan
    • , Herta Flor
    • , Rolf Sprengel
    • , Thomas Kuner
    •  & Rohini Kuner
  • Article |

    A small population of brainstem noradrenaline neurons powerfully modulates global brain function, but how they regulate diverse—and at times opposing—functions is not clear. The authors report that a modular organization in this neuromodulatory system, coupled with context-dependent activation modes, controls the balance between opposing emotional and flexible learning states.

    • Akira Uematsu
    • , Bao Zhen Tan
    • , Edgar A Ycu
    • , Jessica Sulkes Cuevas
    • , Jenny Koivumaa
    • , Felix Junyent
    • , Eric J Kremer
    • , Ilana B Witten
    • , Karl Deisseroth
    •  & Joshua P Johansen

News & Comment

  • News and Views |

    What is the basis for the feeling that someplace or someone is familiar? Molas et al. have identified brain structures involved in signaling familiarity, a necessary element for the expression of preference for novelty.

    • Rebecca D Burwell
    •  & Victoria L Templer
  • News and Views |

    Zika virus infection is associated with birth defects, including microcephaly, but also with disorders of peripheral nerves. Oh et al. use rodent and human cell models to explore how the virus affects the peripheral nervous system.

    • Themasap A. Khan
    •  & Sergiu P. Paşca
  • News and Views |

    Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA–RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.

    • Karl Herrup
    • , Kai-Hei Tse
    •  & Hei-Man Chow
  • News and Views |

    A combination of computational modeling, neuroimaging and a causal manipulation of brain activity in humans reveals how the brain represents beliefs about how our choices will affect those of others we interact with.

    • Amit Etkin
  • News and Views |

    Effectiveness of EGFR treatment is impaired through an early adaptive response. TNF–JNK–Axl–ERK signaling contributes to this primary resistance to EGFR inhibition and might serve as novel target to improve EGFR inhibition.

    • Rolf Warta
    •  & Christel Herold-Mende

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