Regulation of hepatic glucose metabolism in health and disease

The crucial role of the liver in maintaining glucose homoeostasis is disrupted in diabetes mellitus, but therapies could be developed to target hepatic glucose production.

Latest Reviews

  • Review |

    The clinical and metabolic heterogeneity of adult-onset autoimmune diabetes, which encompasses a spectrum of phenotypes, ranging from classic adult-onset type 1 diabetes mellitus to latent autoimmune diabetes in adults, represents a considerable challenge for the management of this disease. In this Review, the authors summarize the definition, pathophysiology and clinical features of adult-onset autoimmune diabetes and discuss their implications for treatment.

    • Raffaella Buzzetti
    • , Simona Zampetti
    •  & Ernesto Maddaloni
  • Review |

    Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by hypercalcaemia and elevated or inappropriately normal serum levels of parathyroid hormone. Here, Walker and Silverberg review the pathogenesis, diagnosis and management of PHPT, focusing on recent advances in the field.

    • Marcella D. Walker
    •  & Shonni J. Silverberg
  • Review |

    Glucocorticoids are essential for adaptation to stressors (allostasis) and in maladaptation resulting from allostatic load and overload. Here, Bruce McEwen and colleagues discuss the mechanisms of glucocorticoid action in the brain and review how glucocorticoids interact with stress mediators.

    • Jason D. Gray
    • , Joshua F. Kogan
    • , Jordan Marrocco
    •  & Bruce S. McEwen
  • Review |

    In addition to controlling cellular lipid metabolism and homeostasis, sterol regulatory element-binding proteins (SREBPs) act as nodes of convergence and divergence within myriad physiological and pathophysiological processes. Here, Shimano and Sato provide a comprehensive overview of the role of SREBPs in health and disease, at the cell, organ and organism levels.

    • Hitoshi Shimano
    •  & Ryuichiro Sato
  • Review |

    Adipose tissue inflammation is an adaptive response to overnutrition in the early stages of obesity, but later becomes maladaptive. Here, Reilly and Saltiel review the cellular and molecular mechanisms of obesity-induced inflammation in adipose tissue and discuss potential therapeutic approaches.

    • Shannon M. Reilly
    •  & Alan R. Saltiel
  • Review |

    Thyroid dysfunction is associated with adverse obstetric and child development outcomes. Here, Tim Korevaar and colleagues put studies from the past decade on reference ranges, thyroid dysfunction determinants, adverse outcome risks and treatment options into perspective.

    • Tim I. M. Korevaar
    • , Marco Medici
    • , Theo J. Visser
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News & Comment

  • News and Views |

    Results from the Reducing with Metformin Vascular Adverse Lesions (REMOVAL) study show for the first time that metformin has a cardiovascular benefit in patients with type 1 diabetes mellitus (T1DM), although the benefit was limited to tertiary outcomes and was modest. Additional measures are therefore needed to reduce cardiovascular disease in patients with T1DM.

    • Janet K. Snell-Bergeon
  • News and Views |

    Dementia is a complication associated with diabetes mellitus. Evidence suggests that patients with diabetes mellitus who have dementia have a unique form of the disease, albeit with similarities to vascular dementia. A recent study by Juraj Secnik and colleagues confirms this suggestion and provides insights into the clinical characteristics and treatment of the disorder.

    • John E. Morley
  • Opinion |

    In this Opinion article, Klose and Feldt-Rasmussen posit that the true risk and disease burden of hypopituitarism after traumatic brain injury might have been overestimated in recent years. Possible reasons for this overestimation are discussed, along with current recommendations for diagnosing and treating the condition.

    • Marianne Klose
    •  & Ulla Feldt-Rasmussen

Collection

Endocrine disruption

Macmillan Publishers

Collection

Endocrine disruption

A collection of articles from Nature Reviews Endocrinology on the biological effects of endocrine-disrupting chemicals and implications for human health.

David Holmes

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