In this Consensus Statement, Garg and colleagues describe the current evidence on the use of cardiovascular magnetic resonance imaging for the assessment of mitral regurgitation, highlight its current clinical utility, and recommend a standardized imaging protocol and report.

In this Perspectives article, Oatmen and colleagues propose that, because abnormal fibroblast populations present in pressure-overload hypertrophy and cancer have similar molecular features, chemotherapeutic agents might be effective in preventing the progression of pressure-overload hypertrophy to heart failure with preserved ejection fraction.

In this Review, Rosenbaum and colleagues give a broad perspective on the genetic causes of dilated cardiomyopathy to provide a context for a discussion of the pragmatic use of genetic testing in heart failure clinics for patients presenting with new-onset dilated cardiomyopathy.

In this Review, Cai and colleagues discuss the complex crosstalk between different oxidase systems and the consequences of this crosstalk in mediating cardiovascular disease processes, focusing on the central role of particular NADPH oxidase isoforms activated in specific cardiovascular diseases.

Non-atherosclerotic processes are important contributors to a substantial number of acute coronary syndrome events. In this Review, Gulati and colleagues discuss the diagnosis, management and prognosis of patients with spontaneous coronary artery dissection, coronary artery embolism, vasospasm, myocardial bridging or stress-induced cardiomyopathy (Takotsubo syndrome).

Inherited arrhythmias are a major cause of sudden cardiac death, particularly among young individuals. In this Review, Offerhaus and colleagues provide an overview of the epidemiology of inherited ventricular arrhythmias, focusing on natural history, prevalence and patient demographics.

Levels of non-HDL cholesterol in the blood are strongly linked with long-term risk of cardiovascular disease, according to a new risk evaluation study that followed-up almost 400,000 individuals without cardiovascular disease at baseline for a median of 13.5 years.

Deficiency in the orphan G protein-coupled receptor 146 (GPR146) decreases blood lipid levels and protects against atherosclerosis in mice independently of LDL receptor activity, according to a new study.

Stem cell therapy does not promote the regeneration or production of new cardiomyocytes in the injured heart but induces a wound healing response that contributes to improved cardiac function.

Udenafil, a phosphodiesterase type 5 inhibitor, improves measures of exercise performance at the ventilatory anaerobic threshold in individuals with Fontan physiology.

In two post-hoc analyses of the DAPA-HF trial, the benefits of dapagliflozin were found to be consistent across all age groups and independent of baseline symptom status.

In patients with a recent myocardial infarction, anti-inflammatory therapy with low-dose colchicine reduces the risk of ischaemic cardiovascular events compared with placebo.