●Cyclin guides the way. Wittenberg, C. Nature 3 March (2005) This News and Views article discusses recent insights into the regulation of cyclin-dependent-kinase activity.

●Research funding, partnership and strategy — a UK perspective. Walport, M. J. & Lynn D. W. Nature Reviews Molecular Cell Biology April (2005)

●Gene–environment interactions in human diseases. Hunter, D. J. Nature Reviews Genetics April (2005)

●Comparative epigenomics of leukemia. Costello, J. F. Nature Genetics March (2005)

●Bacterial toxins and cancer — a case to answer? Lax, A. J. Nature Reviews Microbiology April (2005) The study of bacterial-induced carcinogenesis is in its infancy and, in this Opinion article, the evidence for the oncogenic potential of bacterial toxins is discussed.

●Communicating with Hedgehogs. Hooper, J. E. & Scott, M. P. Nature Reviews Molecular Cell Biology (2005) Damage to the Hedgehog pathway can cause birth defects and cancer. This Review discusses the evolutionarily conserved cellular machinery that is responsible for the molecular mechanisms of Hedgehog signal transduction.

●Genomic approaches in the management and treatment of breast cancer. Chang, J. C., Hilsenbeck, S. G. & Fuqua, S. A. W. British Journal of Cancer 28 February (2005)

●Towards safe non-viral therapeutic gene expression in humans. Glover, D. J., Lipps H. J. & Jans, D. A. Nature Reviews Genetics April (2004)

●Defining 'stemness': Notch and Wnt join forces? Jacobsen, S. E. W. Nature Immunology March (2005)

●Dendritic cells as therapeutic vaccines against cancer. Banchereau, J. & Palucka, A. K. Nature Reviews Immunology April (2005) Dendritic cells regulate T-cell immunity, and this Review discusses how they can be used in the development of effective antitumour immunotherapy protocols.