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Volume 24 Issue 4, April 2024

Black voices, inspired by the Viewpoint on p235.

Cover design: Lara Crow

Research Highlights

  • In this Tools of the Trade, Juliann Shih describes the development of BISCUT, which detects genomic loci that are subject to fitness advantages or disadvantages by interrogating the length distributions of partial somatic copy-number alterations to enable the discovery of new drivers of aneuploidy in cancer.

    • Juliann Shih
    Tools of the Trade

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  • In this Tools of the Trade article, Vakul Mohanty describes the development and use of METAFlux, a computational framework that infers metabolic flux from bulk and single-cell RNA-sequencing data.

    • Vakul Mohanty
    Tools of the Trade
  • Two independent studies published in Nature implicate distal cholesterol biosynthesis in the regulation of ferroptosis and show that 7-dehydrocholesterol (7-DHC) is an endogenous, anti-ferroptotic metabolite.

    • Daniela Senft
    Research Highlight
  • Recently published in Nature, Fan et al. demonstrate that accumulation of advanced glycation end-products in the extracellular matrix of the liver increases viscoelasticity to promote hepatocellular carcinoma growth, independent of stiffness.

    • Gabrielle Brewer
    Research Highlight
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Journal Club

  • In this Journal Club, Taboada and Riechelmann discuss the importance of a study outlining a novel neuroendocrine neoplasm classification system.

    • Rodrigo Gomes Taboada
    • Rachel P. Riechelmann
    Journal Club
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Viewpoint

  • In this Viewpoint article, we asked five Black cancer researchers and clinicians to present their ideas on how we can attract and retain more diverse researchers to the cancer community and how we begin to close the gap in cancer disparities.

    • Kilan C. Ashad-Bishop
    • Onyinye D. Balogun
    • Christina Towers
    Viewpoint
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Reviews

  • This Review provides an overview of the complexity and significance of protein lipidation in cancer, outlines how targeting protein lipidation pathways offer promising avenues for developing cancer treatments, and discusses the current state of drugs targeting these pathways.

    • Edward W. Tate
    • Lior Soday
    • Hening Lin
    Review Article
  • Extrachromosomal DNA (ecDNA) is now accepted as a major contributor to cancer pathogenesis. In this Review, Yan, Mischel and Chang highlight the recent advancements in ecDNA research, providing new insights into the biogenesis and maintenance of ecDNA, as well as its role in altering gene expression and promoting tumour heterogeneity.

    • Xiaowei Yan
    • Paul Mischel
    • Howard Chang
    Review Article
  • In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic factors induce the epigenetic changes necessary for tumorigenesis.

    • Shaopeng Yuan
    • Jorge Almagro
    • Elaine Fuchs
    Review Article
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