Chemistry

  • Article
    | Open Access

    Lipid membrane disruption is often associated with disease but is also essential to a range of biosensing and therapeutic techniques. Here, the authors report on the development of DNA-based particles that, upon exposure to an external cue, can aggregate, disrupt lipid membranes, and arrest the motion of bacteria.

    • Michal Walczak
    • , Ryan A. Brady
    •  & Lorenzo Di Michele
  • Article
    | Open Access

    The chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis for late-stage peptide diversification.

    • Maximilian Stangier
    • , Antonis M. Messinis
    •  & Lutz Ackermann
  • Article
    | Open Access

    The roaming reaction is a common process in the gas phase and in solution, but observation of the involved atomic movements has been challenging. The authors, using femtosecond time-resolved X-ray liquidography, resolve the detailed structural dynamics at the onset of a roaming reaction in the photoinduced isomerization of BiI3 in solution.

    • Eun Hyuk Choi
    • , Jong Goo Kim
    •  & Hyotcherl Ihee
  • Article
    | Open Access

    Electrochemiluminescence (ECL) plays a key role in analysis and sensing but its application is limited by a lack of highly tunable luminophores. Here, the authors demonstrate the design of high efficient ECL luminophores of covalent organic frameworks (COFs) in aqueous media by simultaneously restricting the donor and acceptor to the COFs’ electron configurations and constructing charge transport networks through olefin linkages.

    • Ya-Jie Li
    • , Wei-Rong Cui
    •  & Jian-Ding Qiu
  • Article
    | Open Access

    G protein-coupled receptors (GPCRs) are a critical target in modern drug development across a wide range of indications. Here the authors provide a comprehensive characterization of a typical GPCR, the angiotensin II (AngII) type 1 receptor (AT1R), and provide insight into its activation mechanism that suggest avenues for the design of allosteric GPCR modulators.

    • Shaoyong Lu
    • , Xinheng He
    •  & Jian Zhang
  • Article
    | Open Access

    Single-atom Rh catalysts present superior activity in olefins hydroformylation, yet with limited success in regioselectivity control. Here the authors develop a Rh1 single-atom catalyst with nanodiamond as support, with which good to excellent regioselectivities to branched aldehydes in hydroformylation of terminal olefins are achieved.

    • Peng Gao
    • , Guanfeng Liang
    •  & Fen-Er Chen
  • Article
    | Open Access

    Zero thermal expansion alloys have unique dimensional stability but suffer from inherent brittleness and compositional sensitivity. Here the authors present the one-step eutectic reaction approach to produce a dual-phase alloy with an axial zero expansion and promising mechanical properties.

    • Chengyi Yu
    • , Kun Lin
    •  & Xianran Xing
  • Article
    | Open Access

    Appropriate triboelectric material selection is vital to for high performance direct current triboelectric nanogenerator (DC-TENG). The authors here provide effective selection rules as guideline to select triboelectric materials for DC-TENG to reduce the trial-and-error cost for DC-TENG’s research.

    • Zhihao Zhao
    • , Linglin Zhou
    •  & Zhong Lin Wang
  • Article
    | Open Access

    Sustainable strategies for shepherding active particles are at the heart of many prospective applications. Here, Palacios et al. use the emerging topological properties of a microfluidic maze array to passively guide self-propelled colloids from the interior to the edges of the device.

    • Lucas S. Palacios
    • , Serguei Tchoumakov
    •  & Adolfo G. Grushin
  • Article
    | Open Access

    Stability of zeolite catalysts is a highly desirable property for commercial methanol to olefins conversion but extremely challenging to achieve. Here, the authors combine the catalyst pre-coking and water co-feeding to develop an efficient strategy to enhance the long-term stability of SAPO-34 catalyst.

    • Liu Yang
    • , Chang Wang
    •  & Landong Li
  • Article
    | Open Access

    Ligand-oligonucleotide interactions can integrate both small molecules and proteins into nucleic acid-based circuits. Here the authors design ligand-aptamer complexes to control strand-displacement reactions for versatile ligand transduction.

    • Qiu-Long Zhang
    • , Liang-Liang Wang
    •  & Liang Xu
  • Article
    | Open Access

    Honeycomb layered oxides are an emerging class of materials with peculiar physicochemical properties. Here, the authors report the synthesis and electrochemical energy storage characterisations of a mixed-alkali honeycomb layered oxide material capable of storing Na and K ions simultaneously.

    • Titus Masese
    • , Yoshinobu Miyazaki
    •  & Tomohiro Saito
  • Article
    | Open Access

    This study describes a class of small molecule compounds that promote ABCA1-dependent cholesterol efflux via a non-transcriptional mechanism, the identification of the molecular target by a chemical biology approach, and the potential of these agents for the treatment of chronic kidney diseases and potentially other diseases where lipid accumulation drives disease progression.

    • Matthew B. Wright
    • , Javier Varona Santos
    •  & Alessia Fornoni
  • Article
    | Open Access

    Catalytic amide bond-forming methods is important because they could potentially address the existing limitations of classical methods using superstoichiometric activating reagents. Here the authors show an Umpolung amidation reaction of carboxylic acids with nitroarenes and nitroalkanes enabled by FeI2, P(V)/P(III) and photoredox catalysis that avoids the production of byproducts.

    • Yunyun Ning
    • , Shuaishuai Wang
    •  & Jin Xie
  • Article
    | Open Access

    The identification of catalytically active sites with atomic-scale precision occupies a central place in the theory and practice of heterogeneous catalysis. Here the authors assess the nature of the copper-oxygen bond in a Cu-CHA zeolite and recover the microscopic structure of single-metal sites.

    • Paolo Cleto Bruzzese
    • , Enrico Salvadori
    •  & Mario Chiesa
  • Article
    | Open Access

    Aβ oligomers (AβO) are thought to represent the main toxic species in Alzheimer’s disease but very high Aβ concentrations are required to study them in vitro and it remains unknown what role these off-pathway oligomers play in vivo. Here, the authors use a dimeric variant of Aβ termed dimAβ, where two Aβ40 units are linked, which facilitates to study AβO formation kinetics and they observe that Aβ off-pathway oligomer formation is strongly accelerated at endo-lysosomal pH, while amyloid fibril formation is delayed. Furthermore, the authors demonstrate that dimAβ is a disease-relevant model construct for pathogenic AβO formation by showing that dimAβ AβOs target dendritic spines and induce AD-like somatodendritic Tau missorting.

    • Marie P. Schützmann
    • , Filip Hasecke
    •  & Wolfgang Hoyer
  • Article
    | Open Access

    The detailed understanding of the structural variations during cycling in cathodes for Zn-ion aqueous rechargeable batteries is still limited. Here, the authors utilize atomic-column-resolved scanning transmission electron microscopy to elucidate multiphase evolution during hydrated Zn-Ion insertion in vanadium oxide.

    • Pilgyu Byeon
    • , Youngjae Hong
    •  & Sung-Yoon Chung
  • Article
    | Open Access

    Compared to inorganic materials, the magnetoelectric coupling in macromolecules is still hidden. Here, the authors describe machine learning coupled with additive manufacturing to accelerate the discovery of multiferroic macromolecules with a proton-mediated magnetoelectric coupling effect.

    • Yong Hu
    • , Scott Broderick
    •  & Shenqiang Ren
  • Article
    | Open Access

    While water electrolysis offers a renewable means to obtain H2, it is necessary to understand the roles adopted by catalytic components. Here, authors explore a heterostructured MoSe2/perovskite oxide catalyst that shows multidirectional charge transfer to boost electrocatalytic water splitting.

    • Nam Khen Oh
    • , Jihyung Seo
    •  & Hyesung Park
  • Article
    | Open Access

    Many current immunoassays require multiple washing, incubation and optimization steps. Here the authors present Ratiometric Plug-and-Play Immunodiagnostics (RAPPID), a generic assay platform that uses ratiometric bioluminescent detection to allow sandwich immunoassays to be performed directly in solution.

    • Yan Ni
    • , Bas J. H. M. Rosier
    •  & Maarten Merkx
  • Article
    | Open Access

    Solar-driven CO2 reduction into value-added chemicals and fuels is attracting worldwide attention. Here, substantially enhanced photocatalytic CO2 reduction activity is achieved via the synergy of surface oxygen vacancies and ferroelectric polarization over Bi3TiNbO9 photocatalyst.

    • Hongjian Yu
    • , Fang Chen
    •  & Yihe Zhang
  • Article
    | Open Access

    Despite many reports on nanoparticle-covalent organic frameworks (COF) composites, a universal strategy for the synthesis of monodisperse core-shell structured COF nanocomposites remains challenging. Here, the authors develop a strategy for interfacial growth of highly crystalline COFs on functional nanoparticles with abundant optical, electrical and magnetic properties.

    • Liang Chen
    • , Wenxing Wang
    •  & Xiaomin Li
  • Article
    | Open Access

    Wear reduction in diamond-like carbon interacting with ZDDP-additivated oils is essential for current automotive applications. Here, the authors present an atomic-scale study revealing that this can be achieved by tailoring diamond-like carbon’s stiffness, surface nano-topography, and hydrogen content.

    • Valentin R. Salinas Ruiz
    • , Takuya Kuwahara
    •  & Maria-Isabel de Barros Bouchet
  • Article
    | Open Access

    Fine tuning of mechanical properties in elastomers is important for application of elastomers in flexible devices and biomedical field. Here, the authors prepare a nacre inspired PDMS-montmorrillonite composite with good mechanical properties and demonstrate crack tracing using aggregation-induced emission luminogens.

    • Jingsong Peng
    • , Antoni P. Tomsia
    •  & Qunfeng Cheng
  • Article
    | Open Access

    The generation of non-stabilized alkyl radicals from sulfonium salts has been a challenge for several decades. Here, the authors show the treatment of S-(alkyl) thianthrenium salts, which can generate non-stabilized alkyl radicals as key intermediates that enable controlled and selective reactions under mild photoredox conditions.

    • Cheng Chen
    • , Zheng-Jun Wang
    •  & Zhuangzhi Shi
  • Article
    | Open Access

    Efficient production of benzene from lignin is attractive and of great importance, but has not been realized. Here, the authors develop a strategy to transform lignin into benzene over a RuW/zeolite catalyst in water, and the yield of benzene can be as high as 18.8% on lignin weight basis.

    • Qinglei Meng
    • , Jiang Yan
    •  & Buxing Han
  • Article
    | Open Access

    For many polymers, recycling via mechanical processes is not feasible and these materials are destined for landfills or incineration. Here the authors show an open-loop recycling method for superabsorbent polymers that involves decrosslinking via hydrolysis, an optional chain-shortening step via sonication, and functionalizing via Fischer esterification.

    • P. Takunda Chazovachii
    • , Madeline J. Somers
    •  & Anne J. McNeil
  • Article
    | Open Access

    The authors develop a method to build Manhattan Raman Scattering (MARS) probes based on different core atoms, conjugation ring numbers, and stable isotope substitutions. A quantitative model predicts vibrational frequencies of MARS dyes from structures, which are used in supermultiplexed vibrational imaging.

    • Yupeng Miao
    • , Naixin Qian
    •  & Wei Min
  • Article
    | Open Access

    Dielectric elastomer actuators (DEAs) with large electrically actuated strain can be used in non-magnetic motors, but high stiffness, poor strength and slow response currently limit the application of DEAs. Here, the authors optimize the crosslinking network in a polyacrylate elastomer to enable a DEA with high toughness and actuation strain and use the polyacrylate to build a motor which can be driven under low electric field.

    • Li-Juan Yin
    • , Yu Zhao
    •  & Zhi-Min Dang
  • Article
    | Open Access

    For printed electronics to realize its potential as a sustainable ubiquitous technology, eco-friendly solvents that deliver excellent ink performance must be found. Here, the authors report a free online tool that identifies functional green solvents for solution-processed printed electronics.

    • Christian Larsen
    • , Petter Lundberg
    •  & Ludvig Edman
  • Article
    | Open Access

    Self-assembling peptides have a range of potential applications but developing self-assembling sequences can be challenging. Here, the authors report on a one-bead one-compound combinatorial library where fluorescence is used to detect the potential for self-assembly and identified candidates are evaluated.

    • Pei-Pei Yang
    • , Yi-Jing Li
    •  & Kit S. Lam
  • Article
    | Open Access

    Ternary heterometallic clusters often display intriguing structures and bonding. Here the authors prepare four [Sn2Sb5]3−-based clusters stabilized by coordination of a transition metal ion; analysis of their electronic structure reveals that the resulting cluster displays globally aromatic or antiaromatic character depending on the transition metal ion.

    • Yu-He Xu
    • , Nikolay V. Tkachenko
    •  & Zhong-Ming Sun
  • Article
    | Open Access

    The photodissociation dynamics of small molecules in the vacuum ultraviolet range can have key implications for astrochemical modelling, but revealing such dynamical details is a challenging task. Here the authors, combining high resolution experimental techniques, provide a detailed description of the fragmentation dynamics of selected rotational levels of a predissociated Rydberg state of H2S.

    • Yarui Zhao
    • , Zijie Luo
    •  & Xueming Yang
  • Article
    | Open Access

    PMOs (phosphorodiamidate morpholino oligomers) have huge potential for antisense therapy but complex and slow synthesis limits application. Here, the authors report the development of automated flow synthesis methods which reduce nucleobase coupling times from hours to minutes removing human errors and allow for high-throughput production.

    • Chengxi Li
    • , Alex J. Callahan
    •  & Bradley L. Pentelute
  • Article
    | Open Access

    Toll-like receptor 8 (TLR8) plays essential roles in the innate immune response to viral single-stranded RNA (ssRNA), so small molecule modulators of TLR8 are of interest, however adverse effects limit their use. Here, the authors report a tetrasubstituted imidazole CU-CPD107 with dichotomous behaviour, which inhibits R848-induced TLR8 signaling, but shows synergistic activity in the presence of ssRNA, making it a potential antiviral agent.

    • Yi Yang
    • , Adam Csakai
    •  & Hang Yin
  • Article
    | Open Access

    Practical electrochemical N2 reduction reaction is challenged by competing side reactions. Here a combination of DFT and mikrokinetic modelling reveals the potential-dependent competition between electrochemical ammonia production and hydrogen evolution on a single-site iron catalyst embedded in N-doped graphene.

    • Changhyeok Choi
    • , Geun Ho Gu
    •  & Yousung Jung
  • Article
    | Open Access

    Transition metal-catalyzed regioselective difunctionalizations of alkenes with two different functional groups are useful for preparing organic compounds, but the construction of two new C–C bonds is challenging. Here, the authors report cobalt-catalyzed regioselective difluoroalkylarylation of alkenes with solid arylzinc pivalates and difluoroalkyl bromides, through a cascade Csp3 ‒Csp3/Csp3 ‒Csp2 bond formation.

    • Xinyi Cheng
    • , Xingchen Liu
    •  & Jie Li