Chemistry

Definition

Chemistry is a branch of science that involves the study of the composition, structure and properties of matter. Often known as the central science, it is a creative discipline chiefly concerned with atomic and molecular structure and its change, for instance through chemical reactions.

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Latest Research and Reviews

  • Reviews |

    Allosteric modulation and biased agonism at GPCRs could be manifestations of the same underlying 'conformational selection' mechanism, and these can be harmonized by considering the influence of ligand–receptor residence time and kinetic context.

    • J Robert Lane
    • , Lauren T May
    • , Robert G Parton
    • , Patrick M Sexton
    •  & Arthur Christopoulos
  • Research |

    An atomic model of the primed pre-fusion SNARE–complexin–synaptotagmin-1 complex in neuronal exocytosis accounting for vesicle priming and cooperation in synchronizing and activating evoked release on the sub-millisecond timescale.

    • Qiangjun Zhou
    • , Peng Zhou
    • , Austin L. Wang
    • , Dick Wu
    • , Minglei Zhao
    • , Thomas C. Südhof
    •  & Axel T. Brunger
  • Research |

    Steroid biomarkers provide evidence for a rapid rise of marine planktonic algae between 659 and 645 million years ago, establishing more efficient energy transfers and driving ecosystems towards larger and increasingly complex organisms.

    • Jochen J. Brocks
    • , Amber J. M. Jarrett
    • , Eva Sirantoine
    • , Christian Hallmann
    • , Yosuke Hoshino
    •  & Tharika Liyanage
  • Research |

    The mechanism by which formaldehyde, a potent DNA and protein crosslinking agent, is generated from folate is described, with implications for the treatment of certain cancers.

    • Guillermo Burgos-Barragan
    • , Niek Wit
    • , Johannes Meiser
    • , Felix A. Dingler
    • , Matthias Pietzke
    • , Lee Mulderrig
    • , Lucas B. Pontel
    • , Ivan V. Rosado
    • , Thomas F. Brewer
    • , Rebecca L. Cordell
    • , Paul S. Monks
    • , Christopher J. Chang
    • , Alexei Vazquez
    •  & Ketan J. Patel
  • Research |

    The authors report the crystal structure of the β2 adrenergic receptor in complex with compound 15, an allosteric modulator that binds to an alternative binding pocket.

    • Xiangyu Liu
    • , Seungkirl Ahn
    • , Alem W. Kahsai
    • , Kai-Cheng Meng
    • , Naomi R. Latorraca
    • , Biswaranjan Pani
    • , A. J. Venkatakrishnan
    • , Ali Masoudi
    • , William I. Weis
    • , Ron O. Dror
    • , Xin Chen
    • , Robert J. Lefkowitz
    •  & Brian K. Kobilka

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