Featured
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Outlook |
Softsonics: a device to take blood-pressure readings continuously
The flexible sensors have been developed by one of the finalists for The Spinoff Prize.
- Neil Savage
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Outlook |
Caristo Diagnostics: taking a fresh look at CT scans
A different approach that could predict the risk of having a heart attack puts company on the shortlist for The Spinoff Prize.
- Benjamin Plackett
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Outlook |
Temprian Therapeutics: developing a gene-based treatment for vitiligo
A modified protein to disrupt the autoimmune cascade that can lead to the skin-pigment condition makes the company a finalist for The Spinoff Prize.
- Charles Schmidt
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Outlook |
Forkhead BioTherapeutics: developing a diabetes pill
The drug, which could restart insulin production in people with the disease, is made by one of the finalists of The Spinoff Prize.
- Eric Bender
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Outlook |
Sibel Health: designing vital-sign sensors for delicate skin
A start-up that makes flexible devices to monitor heart rate and blood pressure in premature babies wins The Spinoff Prize.
- Neil Savage
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Article |
The proteome landscape of the kingdoms of life
An advanced proteomics workflow is used to identify 340,000 proteins from 100 taxonomically diverse species, providing a comparative view of proteomes across the evolutionary range.
- Johannes B. Müller
- , Philipp E. Geyer
- & Matthias Mann
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Article |
Hair-bearing human skin generated entirely from pluripotent stem cells
Skin organoids generated in vitro from human pluripotent stem cells form complex, multilayered skin tissue with hair follicles, sebaceous glands and neural circuitry, and integrate with endogenous skin when grafted onto immunocompromised mice.
- Jiyoon Lee
- , Cyrus C. Rabbani
- & Karl R. Koehler
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Technology Feature |
African scientists leverage open hardware
A growing emphasis on do-it-yourself science is helping researchers to equip labs in resource-limited areas.
- Abdullahi Tsanni
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News & Views |
CRISPR tool scales up to interrogate a huge line-up of viral suspects
Rapid, reliable identification of an unknown viral infection is challenging. Use of CRISPR technology can simultaneously detect nucleic acids of many viruses and pinpoint specific ones, such as the virus that causes COVID-19.
- Gregory A. Storch
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Article |
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
The monoclonal antibody S309, identified from memory B cells of an individual infected with SARS-CoV in 2003, or antibody cocktails that contain this antibody potently neutralize SARS-CoV-2.
- Dora Pinto
- , Young-Jun Park
- & Davide Corti
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Correspondence |
Reproducibility: bypass animals for antibody production
- Alison C. Gray
- , Andrew Bradbury
- & Carl A. K. Borrebaeck
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Article |
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets
SARS-CoV-2 modulates central cellular pathways, such as translation, splicing, carbon metabolism, proteostasis and nucleic acid metabolism, in human cells; these pathways can be inhibited by small-molecule inhibitors to prevent viral replication in the cells.
- Denisa Bojkova
- , Kevin Klann
- & Christian Münch
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Article |
RIC-seq for global in situ profiling of RNA–RNA spatial interactions
RNA in situ conformation sequencing (RIC-seq) enables the generation of three-dimensional interaction maps of RNA in cells, which sheds light on the interactions and regulatory functions of RNA.
- Zhaokui Cai
- , Changchang Cao
- & Yuanchao Xue
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Article
| Open AccessMassively multiplexed nucleic acid detection with Cas13
CRISPR-based nucleic acid detection is used in a platform that can simultaneously detect 169 human-associated viruses in multiple samples, providing scalable, multiplexed pathogen detection aimed at routine surveillance for public health.
- Cheri M. Ackerman
- , Cameron Myhrvold
- & Pardis C. Sabeti
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Technology Feature |
Open science takes on the coronavirus pandemic
Data sharing, open-source designs for medical equipment, and hobbyists are all being harnessed to combat COVID-19.
- Mark Zastrow
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Nature Index |
Three researchers who are coming at cancer from all angles
The search for disease mechanisms and treatments is one of the biggest collaborative efforts in science. These researchers are significant contributors.
- Sarah DeWeerdt
- , Mark Zastrow
- & Gemma Conroy
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Nature Index |
Game-changing class of immunotherapy drugs lengthens melanoma survival rates
A transformative treatment is giving hope to some patients with metastatic skin cancers.
- Bianca Nogrady
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Review Article |
Multispecific drugs herald a new era of biopharmaceutical innovation
The development and future prospects of prospectively designed multispecific drugs, which have the potential to transform the biopharmaceutical industry by enabling the targeting of currently inaccessible components of the proteome, are reviewed.
- Raymond J. Deshaies
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Nature Podcast |
Podcast: A plastic-recycling enzyme, and supercooled molecules
Hear about the latest science, with Nick Howe and Shamini Bundell.
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Article |
An engineered PET depolymerase to break down and recycle plastic bottles
Computer-aided engineering produces improvements to an enzyme that breaks down poly(ethylene terephthalate) (PET) into its constituent monomers, which are used to synthesize PET of near-petrochemical grade that can be further processed into bottles.
- V. Tournier
- , C. M. Topham
- & A. Marty
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Outlook |
The pros and cons of screening
Increasingly sensitive tests have raised the risk overdiagnosis. Understanding a person’s chance of disease could reduce the harmful side effects of screening.
- Natasha Gilbert
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Article |
Construction of a human cell landscape at single-cell level
Single-cell RNA sequencing is used to generate a dataset covering all major human organs in both adult and fetal stages, enabling comparison with similar datasets for mouse tissues.
- Xiaoping Han
- , Ziming Zhou
- & Guoji Guo
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News Feature |
How artificial kidneys and miniaturized dialysis could save millions of lives
After decades of slow progress, researchers are exploring better treatments for kidney failure — which kills more people than HIV or tuberculosis.
- Charlotte Huff
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News Feature |
The next chapter for African genomics
Nigeria is poised to become a hub for genetics research, but a few stubborn challenges block the way.
- Amy Maxmen
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News |
Super-precise CRISPR tool enhanced by enzyme engineering
Improvements to a method known as base editing could pave the way for safer gene therapies.
- Heidi Ledford
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News Feature |
The kill-switch for CRISPR that could make gene-editing safer
How anti-CRISPR proteins and other molecules could bolster biosecurity and improve medical treatments.
- Elie Dolgin
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News |
Australian biobank repatriates hundreds of ‘legacy’ Indigenous blood samples
The return is part of a groundbreaking approach that could inspire other institutions grappling with how to use historical samples ethically in research.
- Dyani Lewis
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Article |
Multi-omics profiling of mouse gastrulation at single-cell resolution
Single-cell mapping of chromatin accessibility, DNA methylation and RNA expression during gastrulation in mouse embryos shows characteristic epigenetic changes that accompany formation of the primary germ layers.
- Ricard Argelaguet
- , Stephen J. Clark
- & Wolf Reik
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Editorial |
Expensive treatments for genetic disorders are arriving. But who should foot the bill?
The majority of people with sickle-cell disease are live in the world’s poorest communities and cannot afford the eye-watering costs of treatments.
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Nature Video |
‘Haptic skin’ creates virtual sense of touch
Researchers design flexible membrane to make virtual reality more tactile.
- Geoff Marsh
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Technology Feature |
Got mutation? ‘Base editors’ fix genomes one nucleotide at a time
A new class of CRISPR-based tools efficiently corrects point mutations in cell lines, animal models and perhaps the clinic.
- Sandeep Ravindran
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Career Column |
Founding a global biotechnology summit — while pursuing a PhD
Ipshita Mandal-Johnson teamed up with other graduate students to set up an annual forum to develop tomorrow’s biotechnology leaders. This is what she learnt.
- Ipshita Mandal-Johnson
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News & Views |
CRISPR tool modifies genes precisely by copying RNA into the genome
The ultimate goal of genome editing is to be able to make any specific change to the blueprint of life. A ‘search-and-replace’ method for genome editing takes us a giant leap closer to this ambitious goal.
- Randall J. Platt
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Article |
Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds
Compounds that interact with mutant huntingtin and an autophagosomal protein are able to reduce cellular levels of mutant huntingtin by targeting it for autophagic degradation, demonstrating an approach that may have potential for treating proteopathies.
- Zhaoyang Li
- , Cen Wang
- & Boxun Lu
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News |
Super-precise new CRISPR tool could tackle a plethora of genetic diseases
The system allows researchers more control over DNA changes, potentially opening up conditions that have challenged gene-editors.
- Heidi Ledford
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Article |
Search-and-replace genome editing without double-strand breaks or donor DNA
A new DNA-editing technique called prime editing offers improved versatility and efficiency with reduced byproducts compared with existing techniques, and shows potential for correcting disease-associated mutations.
- Andrew V. Anzalone
- , Peyton B. Randolph
- & David R. Liu
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Outlook |
Unlocking the potential of vaccines built on messenger RNA
The technology could help to boost immunity against cancer, influenza and much more.
- Elie Dolgin
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Letter |
Population imaging of neural activity in awake behaving mice
A genetically encoded fluorescent voltage indicator, SomArchon, is used to image changes in membrane voltage from many neurons simultaneously in multiple brain regions of awake, behaving mice.
- Kiryl D. Piatkevich
- , Seth Bensussen
- & Xue Han
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Letter |
Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary
Juxtaposition of region-specific gut spheroids derived from human pluripotent stem cells in the absence of extrinsic factors results in development of segregated hepato-biliary-pancreatic anlages that recapitulate early morphogenetic events.
- Hiroyuki Koike
- , Kentaro Iwasawa
- & Takanori Takebe
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Outlook |
Accelerating flu protection
Can the latest techniques speed up the dangerously slow production of flu vaccines?
- Eric Bender
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News & Views |
Human embryo implantation modelled in microfluidic channels
An innovative microfluidic device has enabled the modelling of the events that occur in human embryos when they implant in the wall of the uterus. It could be used to help understand early pregnancy loss.
- Amander T. Clark
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Nature Podcast |
Podcast: Modelling early embryos, and male-dominated conferences
Listen to the latest from the world of science, with Benjamin Thompson and Shamini Bundell.
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Letter |
Controlled modelling of human epiblast and amnion development using stem cells
Landmarks of early stages of human embryogenesis can be recapitulated in a highly controllable and scalable fashion by culturing human pluripotent stem cells in a microfluidic device.
- Yi Zheng
- , Xufeng Xue
- & Jianping Fu
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Outlook |
The bioengineering of cannabis
Genetic modification could enable industrial-scale production of cannabinoids that have pharmaceutical potential.
- Elie Dolgin
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Nature Podcast |
Podcast: Carbon-based computing, and depleting ancient-human genomes
Listen to the latest from the world of science, with Shamini Bundell and Benjamin Thompson.
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News |
CRISPR cuts turn gels into biological watchdogs
Wunderkind gene-editing tool used to trigger smart materials that can deliver drugs and sense biological signals.
- Ewen Callaway
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News |
Huge US government study to offer genetic counselling
A firm hired by the National Institutes of Health will work with participants in a research programme that plans to sequence one million genomes.
- Jonathan Lambert
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