Matters Arising |
Featured
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Article |
In vivo genome editing using Staphylococcus aureus Cas9
The physical size of the commonly used Cas9 from Streptococcus pyogenes poses challenges for CRISPR-Cas genome editing systems that use the adeno-associated virus as a delivery vehicle; here, smaller Cas9 orthologues are characterized, and Cas9 from Staphylococcus aureus allowed targeting of the cholesterol regulatory gene Pcsk9 in the mouse liver.
- F. Ann Ran
- , Le Cong
- & Feng Zhang
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News |
Transgenic fish swims up regulatory stream
A fast-growing salmon moves closer to US approval after a fishy delay.
- Amy Maxmen
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News |
Politics holds back animal engineers
Funds and approvals lag for transgenic livestock in US.
- Amy Maxmen
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News |
Animals engineered with pinpoint accuracy
More accurate genetic modification has created allergen-free cow's milk and pigs that could serve as a model for atherosclerosis.
- Amy Maxmen
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Letter |
Androgenetic haploid embryonic stem cells produce live transgenic mice
Mouse androgenetic haploid embryonic stem cell lines can be established by transferring sperm into an enucleated oocyte; the cells maintain haploidy and stable growth over 30 passages, express pluripotent markers, are able to differentiate into all three germ layers, contribute to germlines of chimaeras when injected into blastocysts and can produce fertile progeny that carry genetic modifications to the next generation.
- Wei Li
- , Ling Shuai
- & Qi Zhou
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News |
Artificial jellyfish built from rat cells
Reverse-engineered life form could be used to test drugs.
- Ed Yong
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Correspondence |
Control the bonanza for research eggs
- Marcy Darnovsky
- , Susan Berke Fogel
- & Judy Norsigian
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News |
Cloned human embryo makes working stem cells
Researchers begin to identify past problems with cloning technique.
- David Cyranoski
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Brief Communications Arising |
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
- Mohan Viswanathan
- & Leonard Guarente
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Editorial |
The legacy of Doctor Moreau
Regulators must look past visceral disgust about human–animal hybrids. Strict but sensible rules are needed for research on hybrid embryos and chimaeric animals that could produce therapies.
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Comment |
Regulate research at the animal–human interface
The time is right, says Martin Bobrow, to improve the governance of research involving animals that contain human genetic or cellular material.
- Martin Bobrow
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News |
Regulations proposed for animal–human chimaeras
UK lays out first framework to govern ethically sensitive research field.
- Alison Abbott
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News |
Europe fails to reach deal on cloned meat
EU bodies at odds over the labelling and sale of products from clones and their descendants.
- Barbara Casassus
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News |
Transgenic chickens curb bird flu transmission
Genetic modification quells virus, but questions linger about use in developing countries.
- Virginia Hughes
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Research Highlights |
Gene therapy: Small RNAs aid cell transplants
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News |
Mouse project to find each gene's role
International Mouse Phenotyping Consortium launches with a massive funding commitment.
- Alison Abbott
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Editorial |
An absurd law
Turkey's government is about to pass legislation that could cripple the country's biological research.
Transgenic fish go large
New Zealand's GM cattle under fire