Featured
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Letter |
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface liquid (ASL), and this decrease in pH reduces the ability of ASL to kill bacteria; the findings directly link loss of the CFTR anion channel to impaired defence against bacterial infection.
- Alejandro A. Pezzulo
- , Xiao Xiao Tang
- & Joseph Zabner
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News |
Genetically modified cotton gets high marks in India
Engineered plants increased yields and profits relative to conventional varieties.
- Gayathri Vaidyanathan
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News |
Correction algorithms extend the reach of genome sequencing
Latest sequencers combined with older technology improve accuracy of genome assemblies.
- Monya Baker
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Research Highlights |
Human eye parts in a dish
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Outlook |
Technology: The taste of things to come
Artificial tongues that mimic the human sensory experience could aid the development of better and more consistently flavoured foods.
- Neil Savage
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Letter |
Programmable single-cell mammalian biocomputers
In synthetic biology, the use of regulatory proteins that bind either DNA or RNA to reprogram mammalian cellular functions allows a variety of computational ‘logic circuits’ to be built in a plug-and-play manner, which may pave the way for precise and robust control of future gene-based and cell-based therapies.
- Simon Ausländer
- , David Ausländer
- & Martin Fussenegger
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News & Views |
Reprogramming the injured heart
When the heart is injured, the muscle does not regenerate and scars are produced. This process can be attenuated in the hearts of live mice by forcing scar-forming cells to become muscle cells. See Articles p.593 & p.599
- Nathan J. Palpant
- & Charles E. Murry
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Feature |
Biotechnology investment: Gains and losses
Connecticut's investment initiatives are boosting research prospects, despite the region's languishing pharmaceutical sector.
- Karen Kaplan
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News |
Stem cells take root in drug development
Increasing use by industry showcases stem cell technology as research tool.
- Daniel Cressey
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Research Highlights |
High-voltage plant proteins
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Research Highlights |
Solar panel in the eye
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News |
Restoring sight with wireless implants
A combination of video goggles and photovoltaic retinal implants could make vision restoration more practicable.
- Leigh Phillips
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Research Highlights |
On-demand drug release
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Research Highlights |
Radio remote control of genes
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Research Highlights |
High-throughput cell stretcher
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Review Article |
Engineering the third wave of biocatalysis
Over the past ten years, protein engineering has established biocatalysis as a practical and environmentally friendly alternative to traditional forms of catalysis both in the laboratory and in industry.
- U. T. Bornscheuer
- , G. W. Huisman
- & K. Robins
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News |
Drug-making plant blooms
Approval of a ‘biologic’ manufactured in plant cells may pave the way for similar products.
- Amy Maxmen
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News |
Remote-controlled genes trigger insulin production
Nanoparticles heated by radio waves switch on genes in mice
- Helen Shen
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News |
South Korea steps up stem-cell work
Regenerative medicine gets cash boost but stricter regulations are needed to ensure safety.
- Soo Bin Park
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News |
Enzymes grow artificial DNA
Synthetic strands with different backbones replicate and evolve just like the real thing.
- Helen Shen
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Research Highlights |
Injectable protein nanofactories
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News |
Nanomaterials offer hope for cerebral palsy
Rabbits with brain injuries hop again after treatment with dendrimers.
- Amy Maxmen
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News |
Regenerative medicine repairs mice from top to toe
Three separate studies in mice show normal function can be restored to hair, eye and heart cells.
- Leila Haghighat
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Research Highlights |
Cell transplants repair colon
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News |
The rise of the 'narciss-ome'
Profiles of a researcher's genes, proteins and more show personalized genomic medicine in action.
- Carina Dennis
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News & Views |
Favouring the unfavoured
The naturally occurring antibiotic lasalocid A contains a chemical structure that is not expected to form readily. The enzyme that catalyses the formation of this structure has been identified, and its activity is a revelation. See Letter p.355
- David E. Cane
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Comment |
Four steps to avoid a synthetic-biology disaster
Assess the ecological risks of synthetic microbes before they escape the lab, say Genya V. Dana, Todd Kuiken, David Rejeski and Allison A. Snow.
- Genya V. Dana
- , Todd Kuiken
- & Allison A. Snow
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Q&A |
Turning point: Christopher Wilson
After finding virtual particles, a physicist turns to proteomics.
- Virginia Gewin
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News |
Nanopore genome sequencer makes its debut
Technique promises it will produce a human genome in 15 minutes.
- Erika Check Hayden
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News |
One genome from many
Researchers extract genome for single organism from water sample.
- Virginia Gewin
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Research Highlights |
An eye for gene repair
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News |
French institute prepares for gene-therapy push
Genethon relaunches itself as a force for translational medicine.
- Alison Abbott
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News |
Biofuel from beneath the waves
Engineered bacterium can produce ethanol directly from seaweed.
- Zoe Cormier
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News Explainer |
Say hello to intelligent pills
Digital system tracks patients from the inside out.
- Daniel Cressey
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Research Highlights |
Silkworms spin spider-like silk
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News Feature |
Stem-cell research: Never say die
With a history of public blunders, can Advanced Cell Technology make embryonic stem-cell therapies a reality?
- Corie Lok
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News |
Brain electrodes fix depression long term
First placebo-controlled trial of implanted electrodes is positive.
- Alison Abbott
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Outlook |
Perspective: All systems go
Systems science can provide guidance in capturing the complementary approaches to healthcare, says Jan van der Greef.
- Jan van der Greef
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Outlook |
Biodiversity: Endangered and in demand
With an ingredients list that includes rhino horn and tiger bone, traditional Asian medicine is on a collision course with wildlife preservation.
- Duncan Graham-Rowe
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Outlook |
Modernization: One step at a time
The repertoire of traditional Chinese medicine could offer rich pickings for modern drug developers, but researchers must first define and test herbal concoctions.
- Zhiguo Xu
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Article |
A sensing array of radically coupled genetic ‘biopixels’
Thousands of quorum-sensing Escherichia coli colonies are synchronized over centimetres using redox signalling to create ‘biopixels’ that can sense trace amounts of arsenic in water.
- Arthur Prindle
- , Phillip Samayoa
- & Jeff Hasty
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News |
Video animation: RNA interference
A video explaining RNA interference from Nature Reviews Genetics.
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Research Highlights |
Recharge through the skin
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Q&A |
Turning point: Jimmy Lin
Computational geneticist takes time away from academic pursuits to help kids with rare diseases.
- Virginia Gewin
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Books & Arts |
Molecular biology: Seed of revolution
Michael A. Goldman hails the first English translation of the three-man paper that launched molecular biology.
- Michael A. Goldman
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Seven Days |
Seven days: 9–15 December 2011
The week in science: boost for gene therapy; EPA reports concern over fracking; and a fresh clue to ancient water on Mars.
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Research Highlights |
Two-in-one biofuel maker
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