When the heart is injured, the muscle does not regenerate and scars are produced. This process can be attenuated in the hearts of live mice by forcing scar-forming cells to become muscle cells. See Articles p.593 & p.599
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References
Qian, L. et al. Nature 485, 593–598 (2012).
Song, K. et al. Nature 485, 599–604 (2012).
Davis, R. L., Weintraub, H. & Lassar, A. B. Cell 51, 987–1000 (1987).
Murry, C. E., Kay, M. A., Bartosek, T., Hauschka, S. D. & Schwartz, S. M. J. Clin. Invest. 98, 2209–2217 (1996).
Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).
Ieda, M. et al. Cell 142, 375–386 (2010).
Pang, Z. P. et al. Nature 476, 220–223 (2011).
Vierbuchen, T. et al. Nature 463, 1035–1041 (2010).
Szabo, E. et al. Nature 468, 521–526 (2010).
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. Nature 455, 627–632 (2008).
Sen, K. et al. Am. J. Pathol. 179, 1756–1767 (2011).
Cheng, J., Wang, Y., Liang, A., Jia, L. & Du, J. Circ. Res. 110, 230–240 (2012).
Laflamme, M. A. & Murry, C. E. Nature 473, 326–335 (2011).
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Palpant, N., Murry, C. Reprogramming the injured heart. Nature 485, 585–586 (2012). https://doi.org/10.1038/485585a
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DOI: https://doi.org/10.1038/485585a
