Research Highlights |
Featured
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News & Views |
Chemical ecology of pain
The venom of the Texas coral snake causes excruciating pain. The discovery of the venom's pain-inducing component opens up opportunities for studying predator–prey interactions and for pain research. See Letter p.410
- Baldomero M. Olivera
- & Russell W. Teichert
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Research Highlights |
Sterile males for mosquito control
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News |
Research cuts hit the DNA business
Makers of sequencing machines hope for profits in the clinic.
- Erika Check Hayden
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Letter |
Mapping intact protein isoforms in discovery mode using top-down proteomics
- John C. Tran
- , Leonid Zamdborg
- & Neil L. Kelleher
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Letter |
Biomimetic self-templating supramolecular structures
- Woo-Jae Chung
- , Jin-Woo Oh
- & Seung-Wuk Lee
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Article |
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
- Eric L. Greer
- , Travis J. Maures
- & Anne Brunet
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News |
Ancient Greek ships carried more than just wine
DNA tests of shipwrecked jars illuminate early trade markets in the Mediterranean.
- Jo Marchant
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Editorial |
More than teeth
The bizarre-looking naked mole rat is a worthy member of the genome club.
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News & Views Forum |
Triple genomes go far
A technique called somatic-cell nuclear transfer has been applied to human oocytes, resulting in the generation of personalized stem cells, albeit genetically abnormal ones. Two experts discuss the biomedical significance of this work and the ethical issues surrounding the use of human oocytes in research. See Article p.70
- George Q. Daley
- & Jan Helge Solbakk
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News |
Europe to map the human epigenome
DNA-modification studies get a multi-million euro boost.
- Alison Abbott
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World View |
Why animal research needs to improve
Many of the studies that use animals to model human diseases are too small and too prone to bias to be trusted, says Malcolm Macleod.
- Malcolm Macleod
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Letter |
Theta-paced flickering between place-cell maps in the hippocampus
- Karel Jezek
- , Espen J. Henriksen
- & May-Britt Moser
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Research Highlights |
Tumours light up in surgery
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News |
Glowing cells guide cancer surgeons
Tumour-specific label pinpoints malignant cells.
- Zoe Cormier
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Research Highlights |
Mobile imaging of the mouse brain
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News |
Yeast thrives with partially synthetic genome
Study paves way for large-scale engineering of complex cells.
- Roberta Kwok
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Article
| Open AccessMouse genomic variation and its effect on phenotypes and gene regulation
- Thomas M. Keane
- , Leo Goodstadt
- & David J. Adams
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Letter |
Synthetic chromosome arms function in yeast and generate phenotypic diversity by design
- Jessica S. Dymond
- , Sarah M. Richardson
- & Jef D. Boeke
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Letter |
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
- Georg B. Ehret
- , Patricia B. Munroe
- & Toby Johnson
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Article |
Diffraction-unlimited all-optical imaging and writing with a photochromic GFP
- Tim Grotjohann
- , Ilaria Testa
- & Stefan W. Hell
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Letter |
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans
- Caroline J. Breitbach
- , James Burke
- & David H. Kirn
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Letter
| Open AccessThe genome of the green anole lizard and a comparative analysis with birds and mammals
- Jessica Alföldi
- , Federica Di Palma
- & Kerstin Lindblad-Toh
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Research Highlights |
Skin-deep electronics
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Research Highlights |
A map of gene copy numbers
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News |
Set a bug to kill a bug
Engineered bacteria attack lethal infection with its own weapons.
- Marian Turner
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News |
Cell therapy fights leukaemia
Patchwork receptors target immune cells against cancer.
- Heidi Ledford
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Letter |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- Stephen Sawcer
- , Garrett Hellenthal
- & Alastair Compston
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News |
Female mosquitoes tricked by spermless males
Findings present potential strategy to control spread of malaria.
- Natasha Gilbert
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News |
Gene pool offers way to save Mexican oasis
Commercializing genetic wealth will test biodiversity treaty.
- Nicola Jones
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Letter |
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
- Johannes Zuber
- , Junwei Shi
- & Christopher R. Vakoc
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Article |
Neocortical excitation/inhibition balance in information processing and social dysfunction
- Ofer Yizhar
- , Lief E. Fenno
- & Karl Deisseroth
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Research Highlights |
Bacteria 'blink' to expel molecules
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News |
Chip chips away at the cost of a genome
Ion-sensing method offers cheap sequencing in record time.
- Gwyneth Dickey Zakaib
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Article
| Open AccessAn integrated semiconductor device enabling non-optical genome sequencing
- Jonathan M. Rothberg
- , Wolfgang Hinz
- & James Bustillo
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Article |
The landscape of recombination in African Americans
- Anjali G. Hinch
- , Arti Tandon
- & Simon R. Myers
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News |
How to build a better mouse
The Collaborative Cross project will boost diversity and help the hunt for disease genes.
- Ewen Callaway
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News |
A kinder, gentler defibrillator
A new technique could lower the intensity of the shock needed to reset electrical instabilities in the heart.
- Alla Katsnelson
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Letter |
Low-energy control of electrical turbulence in the heart
- Stefan Luther
- , Flavio H. Fenton
- & Eberhard Bodenschatz
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News |
Mice with human livers deal with drugs the human way
'Humanized' mice could provide better assessment of drugs' toxicity for humans.
- Marian Turner
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Article
| Open AccessGenome sequence and analysis of the tuber crop potato
- Xun Xu
- , Shengkai Pan
- & Richard G. F. Visser
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Technology Feature |
Inside the minds of mice and men
Monitoring technologies and genetic engineering are producing a growing array of animal models for psychiatric disorders, but researchers are still learning how best to use them.
- Monya Baker
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Letter |
The ribosome uses two active mechanisms to unwind messenger RNA during translation
- Xiaohui Qu
- , Jin-Der Wen
- & Ignacio Tinoco
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News |
X-rays illuminate fossil pigment
A new technique gives clues to the shading of fossil animals.
- Gwyneth Dickey Zakaib
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News |
Imaging animals for better research
Modern techniques can cut the number of animals used and improve data quality.
- Daniel Cressey
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Letter |
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
- Garret D. Stuber
- , Dennis R. Sparta
- & Antonello Bonci
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