Giant viruses

Giant virus biology and diversity in the era of genome-resolved metagenomics

  • Frederik Schulz
  • Chantal Abergel
  • Tanja Woyke
Review Article



  • Sewage surveillance could provide information on the resistance situation in the underlying population and on environmental transmission risks. There are opportunities to make such surveillance data more informative and actionable, but there are also challenges.

    • D. G. Joakim Larsson
    • Carl-Fredrik Flach
    • Ramanan Laxminarayan
  • This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its fitness and virulence.

    • Agustina Taglialegna
    Research Highlight
  • This month’s Genome Watch highlights how genome sequencing can be used to understand the strain-level diversity, evolution and spatial structure of the human microbiome, and to inform therapeutic strategies.

    • Gemma G. R. Murray
    • Chrispin Chaguza
    Genome Watch
  • This study reports that the Chlamydia trachomatis effector TepP modulates epithelial tight junctions to promote infection.

    • Andrea Du Toit
    Research Highlight
  • This study characterized the role of periplasmic PgfA in mycobacterial growth and division.

    • Andrea Du Toit
    Research Highlight
  • This study reports the identification of a highly divergent lineage of SARS-CoV-2 in white-tailed deer and provides evidence of deer-to-human transmission.

    • Andrea Du Toit
    Research Highlight
SARS-CoV-2 virions


The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has led to substantial disease and millions of deaths worldwide, with devastating socio-economic impacts. This Series contains articles from Nature Reviews Microbiology that explore the basic biology, epidemiology, emergence, evolution and pathogenesis of SARS-CoV-2 and pathogenic coronaviruses, as well as options for the control and prevention of COVID-19.


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