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Mechanisms of metastatic colorectal cancer
Metastatic colorectal cancer (mCRC) has a poor prognosis, and therapeutic options are limited. This Review provides a comprehensive overview of the genetic and molecular underpinnings of mCRC, discussing the therapeutic potential arising from this knowledge.
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MASLD/NAFLD
Fuelled by increasing obesity rates, metabolic dysfunction associated steatotic liver disease (MASLD, formerly known as NAFLD) has emerged as a leading global cause of chronic liver disease in the past few decades. Despite growing prevalence, the factors influencing MASLD development and subsequent progression to metabolic dysfunction associated steatohepatitis (MASH), liver fibrosis, cirrhosis and hepatocellular carcinoma are poorly understood. In this article series, Nature Reviews Gastroenterology & Hepatology explores the epidemiology of MASLD, disease mechanisms and therapeutics, and clinical approaches to diagnosis and management.