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Integration of differential and conventional RNA sequencing and transposon mutant fitness data for Bacteroides thetaiotaomicron grown under 15 different conditions provides an expression atlas, expands the regulatory RNA repertoire and reveals that the small RNA MasB regulates susceptibility to tetracyclines.
A DNA barcoding approach enables discrimination between bacterial strains that could not be distinguished with conventional microbial marker gene amplicon sequencing techniques.
WISH-tags can be used in combination with quantitative polymerase chain reaction or next-generation sequencing to decipher population dynamics at the strain level within plant and mammalian microbiotas.
Metabolic engineers and synthetic biologists can produce recombinant proteins at scale without royalty payments, or strain distribution constraints, using OPENPichia.
An analysis of over 2,000 genomes from Human Microbiome Project metagenomic data led to the identification of several extended- and narrow-spectrum antibiotics against clinical multidrug-resistant pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.
A citizen-science approach is used to map the vaginal microbiome of 3,345 women and identify associations with health, life-course and lifestyle factors.
Faecal viromes of 647 healthy infants were deeply sequenced to identify more than 230 previously undescribed gut virus families, expanding known diversity within the human infant gut virome.
Eighty-nine percent of the Trypanosomabrucei proteome is mapped using fluorescence microscopy and cell lines expressing endogenously tagged proteins, and presented in a resource for the community named TrypTag.org.
A resource of >3,700 Ser/Thr protein kinase-substrate interactions and their transcriptional effects establishes O-phosphorylation as a dominant signalling mechanism in Mycobacterium tuberculosis.
Evolutionary analysis guided by predicted structures of AlphaFold 2 elucidates novel aspects of rapidly evolving pathogen effectors from fungal phytopathogens.
The metavirome of 31 tick species sheds light on the diversity and distinct evolution of tick-associated RNA viruses, and lays the foundation for better understanding of tick–virus interaction.
This Resource combines amplicon sequencing, shotgun metagenomic sequencing and untargeted metabolomics to provide a global view of microbial–metabolite associations across Earth’s environments.
Metagenomic analysis of the gut virome along the mammalian gastrointestinal tract of two mammalian species reveals the biogeography of bacteriophage, including region- and species-specific variations in virome composition.