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    • How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

      • Severin Mühleder
      • Rui Benedito
      News & Views
    • During the repair of DNA breaks by homologous recombination, damaged DNA seeks out intact, similar in sequence segments to use as a template. In this issue, Piazza, Bordelet and colleagues describe three-dimensional chromosome architecture remodelling during homologous recombination and show that cohesin restricts homology search in cis, independently of sister chromatid cohesion.

      • Argyris Papantonis
      • Vassilis Roukos
      News & Views
    • In this Perspective, Teichmann and colleagues present ongoing efforts from consortia of the Human Cell Atlas to harmonize and integrate data sources into a reference cell ontology and the contributions of cell ontologies to discovery.

      • David Osumi-Sutherland
      • Chuan Xu
      • Sarah A. Teichmann
      Perspective
    • In this Perspective, Börner et al. discuss initiatives by 16 consortia to construct a Human Reference Atlas (HRA) comprising reference organs linked to tables that name major anatomical structures, cell types, plus biomarkers (ASCT+B) and present examples of HRA usage.

      • Katy Börner
      • Sarah A. Teichmann
      • Griffin Weber
      Perspective
    • FGFR-altered triple negative breast cancer (TNBC) develops adaptive resistance to FGFR inhibitor therapy. A new study shows that sustained FGFR inhibition causes SWI/SNF complex eviction at YAP-recruited enhancers followed by increased mTORC1 activity. Dual inhibition of YAP or mTORC1 and FGFR has a synergistic effect on tumour growth.

      • Krystal A. Orlando
      • Paul A. Wade
      News & Views
Mapping the cells of the body

Mapping the cells of the body

In this Focus, we highlight progress in the use of single-cell technologies to analyze large datasets to map cellular diversity in entire organisms, examine cell types and states, cellular interactions and functions.
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