When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading to excision of the damaged site and DNA synthesis to fill the gap. Three new studies show that, for aldehyde-induced DNA crosslinks, repair is activated by the same factors, but without base excision and gap filling.
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Saponaro, M. Adding a transcription-coupled repair pathway. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01399-7
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DOI: https://doi.org/10.1038/s41556-024-01399-7
