Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Basic science is not just a foundation

Intellectual freedom for scientists, unconstrained by commercial interests and direct application, fuels unexpected discoveries. Curiosity-driven, basic science has yielded a deeper understanding of how life forms develop and function in their environment and has had wide implications for health and our planet. Investing in this is vital for scientific progress and is worth protecting in a democracy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

References

  1. Van Doren, M., Broihier, H. T., Moore, L. A. & Lehmann, R. Nature 396, 466–469 (1998).

    Article  PubMed  Google Scholar 

  2. Nüsslein-Volhard, C., Frohnhöfer, H. G. & Lehmann, R. Science 238, 1675–1681 (1987).

    Article  PubMed  Google Scholar 

  3. Ephrussi, A. & Lehmann, R. Nature 358, 387–392 (1992).

    Article  CAS  PubMed  Google Scholar 

  4. Banisch, T. U. et al. Dev. Cell 56, 1742–1755.e4 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Schor, N. F. Neurology 80, 2070–2075 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Rosenberg, B., Van Clamp, L. & Krigas, T. Nature 205, 698–699 (1965).

    Article  CAS  PubMed  Google Scholar 

  7. Pardi, N., Hogan, M. J., Porter, F. W. & Weissman, D. Nat. Rev. Drug Discov. 17, 261–279 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bennett, C. F., Krainer, A. R. & Cleveland, D. W. Annu. Rev. Neurosci. 42, 385–406 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Bassat, E. & Tanaka, E. M. Curr. Opin. Cell Biol. 73, 117–123 (2021).

    Article  CAS  PubMed  Google Scholar 

  10. Reddien, P. W. The Cellular and Molecular Basis for Planarian Regeneration. Cell 175, 327–345 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Poeschla, M. & Valenzano, D. R. J. Exp. Biol. 223, jeb209296 (2020).

    Article  PubMed  Google Scholar 

  12. Oka, K., Yamakawa, M., Kawamura, Y., Kutsukake, N. & Miura, K. Annu. Rev. Anim. Biosci. 11, 207–226 (2023).

    Article  PubMed  Google Scholar 

  13. Goldstein, B. Curr. Top. Dev. Biol. 147, 173–198 (2022).

    Article  CAS  PubMed  Google Scholar 

  14. Gasulla, F., Del Campo, E. M., Casano, L. M. & Guéra, A. Plants 10, 807 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795–801 (1980).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

I am grateful for many discussions with friends and colleagues in conceptualizing the opinions expressed here, but most importantly to my collaborator on this essay, L. Girard, Director of Strategic Communication, Whitehead Institute. Much of the opinions expressed here were shaped by my experience as a trainee and investigator at the Max Planck Institute for Developmental Biology in Tübingen Germany, the Medical Research Council in Cambridge UK, the Skirball Institute at New York University Langone Medical Center, the Whitehead Institute, the Massachusetts Institute of Technology and the Howard Hughes Medical Institute.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ruth Lehmann.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lehmann, R. Basic science is not just a foundation. Nat Cell Biol 26, 8–10 (2024). https://doi.org/10.1038/s41556-023-01308-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-023-01308-4

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing