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Mechanobiology

Tissue pressure and YAP during organogenesis

Nature Cell Biology volume 26, pages 510–511 (2024)Cite this article

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Organ morphogenesis begins with proliferation, which results in tissue pressures and site-specific YAP expression, nuclear translocation and signalling. A study now reports the involvement of anisotropy, localized pressure and YAP signalling in organizer-forming cascades, introducing a new chapter of molecular mechanobiology of organogenesis.

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Fig. 1: Tissue mechanics drive enamel knot formation in the mouse incisor.

References

  1. Thesleff, I. Aust. Dent. J. 59, 48–54 (2014).

    Article  PubMed  Google Scholar 

  2. Shroff, N. & Xu, P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01380-4 (2024).

    Article  PubMed  Google Scholar 

  3. Kim, W. & Jho, E.-h BMB Rep. 51, 106 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Zheng, Y. & Pan, D. Dev. Cell 50, 264–282 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sebé-Pedrós, A., Zheng, Y., Ruiz-Trillo, I. & Pan, D. Cell Rep. 1, 13–20 (2012).

    Article  PubMed  Google Scholar 

  6. Pandya, M. et al. J. Dev. Biol. 10, 14 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Spemann, H. & Mangold, H. Int. J. Dev. Biol. 45, 13–38 (2001).

    CAS  PubMed  Google Scholar 

  8. Wolpert, L. Int. J. Dev. Biol. 53, 659–662 (2009).

    Article  PubMed  Google Scholar 

  9. Niehrs, C. Nat. Rev. Genet. 5, 425–434 (2004).

    Article  CAS  PubMed  Google Scholar 

  10. Chin, L., Xia, Y., Discher, D. E. & Janmey, P. A. Curr. Opin. Chem. Eng. 11, 77–84 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Gargalionis, A. N., Basdra, E. K. & Papavassiliou, A. G. J. Cell. Bio. 119, 4304–4308 (2018).

    Article  CAS  Google Scholar 

  12. Giancotti, F. G. & Ruoslahti, E. Science 285, 1028–1033 (1999).

    Article  CAS  PubMed  Google Scholar 

  13. Gingras, A. R. & Ginsberg, M. H. Curr. Biol. 30, R397–R400 (2020).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

Generous funding by NIDCR grants DE026198 and DE027930 to T.G.H.D. is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Oral and Craniofacial Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

    Qian Xu & Thomas G. H. Diekwisch

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  1. Qian Xu
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  2. Thomas G. H. Diekwisch
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Correspondence to Thomas G. H. Diekwisch.

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The authors declare no competing interests.

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Xu, Q., Diekwisch, T.G.H. Tissue pressure and YAP during organogenesis. Nat Cell Biol 26, 510–511 (2024). https://doi.org/10.1038/s41556-024-01392-0

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