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Cell death

RIPK1 and necroptosis role in premature ageing

Nature Cell Biology volume 26, pages 508–509 (2024)Cite this article

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Progeria, or premature ageing, is a devastating condition caused by defects in the nuclear envelope and is associated with systemic inflammation. A study now shows in animal models that inhibiting necroptosis, and particularly activity of the RIPK1 kinase, reduces inflammation and results in a meaningful extension in lifespan1.

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Fig. 1: A schematic indicating potential signalling outputs from TNF/TNFR1 in wild-type and Zmpste24−/− cells.

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute, Parkville, Victoria, Australia

    Panxue Wang & John Silke

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  1. Panxue Wang
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  2. John Silke
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Correspondence to John Silke.

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Competing interests

J.S. is a consultant for a company developing RIPK1 inhibitors. P.W. has no competing interests to declare.

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Wang, P., Silke, J. RIPK1 and necroptosis role in premature ageing. Nat Cell Biol 26, 508–509 (2024). https://doi.org/10.1038/s41556-024-01390-2

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