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Volume 26 Issue 3, March 2024

ER-phagy during neurogenesis

Quantitative proteomics analyses show the importance of selective autophagy in endoplasmic reticulum (ER) remodelling across neuronal subcompartments and decode the substrate selectivity of ER-phagy receptors during in vitro neurogenesis.

See Hoyer et al. and News & Views by Molinari

Image: Cristina Capitanio, Max Planck Institute of Biochemistry, Martinsried, Germany. Cover Design: Lauren Heslop

Correspondence

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World View

  • In this piece, I share a personal encounter that underscores the glaring gaps in conference accessibility and challenges faced by disabled academics. I reveal historical biases and resistance to change and propose ways to transform conferences into more inclusive spaces, ensuring that all scientists can fully participate in the scientific discourse.

    • Urszula Lucja McClurg
    World View
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News & Views

  • Biomolecular condensates are recognized for their ability to compartmentalize the cytoplasm without bounding membranes, but the degree to which they organize the cytoplasm has not been clear. A new study reveals that condensates at a scale of 100 nm are responsible for the organization of at least 18% of the cytoplasmic proteome.

    • Leshani Ahangama Liyanage
    • Jonathon A. Ditlev
    News & Views
  • How do metabolic stresses trigger catabolic autophagy for cell survival? A study now reveals that the metabolite sensor Pho81 integrates into and activates the kinase activity of the Atg1 complex for pexophagy triggered by phosphate starvation. This demonstrates the plasticity of the autophagy-initiating Atg1 complex.

    • Xiaoli Ma
    • Hong Zhang
    News & Views
  • The endoplasmic reticulum (ER) controls the synthesis of lipids and proteins and Ca2+ homeostasis, as well as contacting other organelles and the plasma membrane. A study now looks at a process by which this compartment is remodelled in axons during neurogenesis: the lysosomal clearance of ER subdomains, driven by FAM134 and CCPG1 proteins.

    • Maurizio Molinari
    News & Views
  • Mechanical forces are ubiquitously present in biology. In recent years, it has become clear how plasma membranes detect these forces — but how do intracellular organelles such as lysosomes do the same, and what might be the functions of such intracellular mechanosensing? Answers may come through a report of a lysosomal mechanosensitive ion channel, TMEM63.

    • Erika Riederer
    • Dejian Ren
    News & Views
  • Activation of innate immunity has been linked to the progression of type 1 diabetes. A study now shows that overexpression of METTL3, a writer protein of the m6A machinery that modifies mRNA, restrains interferon-stimulated genes when expressed in pancreatic β-cells, identifying it as a promising therapeutic target.

    • Balasubramanian Krishnamurthy
    • Helen E. Thomas
    News & Views
  • As a major microenvironmental component in B cell lymphomas, T cells are highly relevant for current immunotherapeutic treatment strategies of such tumours. A study now provides an unprecedented multimodal insight into the composition and features of T cell subsets of the four main types of nodal B cell non-Hodgkin lymphoma.

    • Ralf Küppers
    News & Views
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Research Briefings

  • Contractile activity of both the epithelium and underlying mesenchyme are required for epithelial deformation and cell fate acquisition during early mouse hair follicle development. Subsequently, localized basement membrane remodelling facilitates the release of tension-generated pressure to promote cell divisions, tissue fluidification and downgrowth of the developing hair follicle.

    Research Briefing
  • The generation of clathrin-coated vesicles during endocytosis requires the co-ordinated recruitment of dozens of proteins to the plasma membrane. We discovered that the plant TPLATE (or TSET) complex (TPC) undergoes biomolecular condensation through interactions with plasma membrane phospholipids and, via weak multivalent interactions, recruits clathrin and other endocytic proteins to facilitate the efficient progression of endocytosis.

    Research Briefing
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Review Articles

  • Mathiowetz and Olzmann review our current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of lipid droplets in regulating fatty acid flux in lipotoxicity and cell death.

    • Alyssa J. Mathiowetz
    • James A. Olzmann
    Review Article
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