• Artistic rendition of metabolic signaling

    Join us November 1, 2022—November 3, 2022 for a virtual meeting presented by Nature Cell Biology, Nature Reviews Molecular and Cell Biology, and Nature Metabolism. We are pleased to bring together experts from diverse fields to discuss recent advances in understanding metabolic signalling pathways in organelles, cells, and tissues, and how these come together to control systemic metabolism.

  • A swirl of cells in brightly contrasting colors

    In this collection, we highlight recent papers published across Nature Portfolio journals on topics including embryonic development and stem cells, clinical and translational research, stem cell-based tissue engineering, and tissue stem cells.

  • To address health disparities and facilitate increasingly personalized treatments, Horwitz, Riley, Millan & Gunawardane call for the development of new models for basic and disease research that reflect diverse ancestral backgrounds and sex, and for the inclusion of diverse populations among donors and research participants.

  • Developing embryos and organs

    In this Focus, we highlight progress in the use of single-cell technologies to analyze large datasets to map cellular diversity in entire organisms, examine cell types and states, cellular interactions and functions.

Nature Cell Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

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    • NADPH levels serve as a biomarker of sensitivity to ferroptosis, but the regulators that detect cellular NADPH levels and modulate downstream ferroptosis responses are unknown. A study now identifies MARCHF6 in the ubiquitin system as an NADPH sensor that suppresses ferroptosis.

      • Chao Mao
      • Boyi Gan
      News & Views
    • In this Review, Polyak and colleagues discuss cellular and microenvironmental mechanisms that contribute to intratumour heterogeneity and how this affects immune escape and tumour progression.

      • Zheqi Li
      • Marco Seehawer
      • Kornelia Polyak
      Review Article
    • Aberrant subcellular localization of proteins contributes to the pathogenesis of cancer. A study now reports that the mis-localization of METTL3, a nuclear N6-adenosine methyltransferase, to the cytoplasm promotes gastric cancer by enhancing mRNA translation of a subset of oncogenes, independently of the N6-methyladenosine (m6A) modification.

      • Sylvain Delaunay
      • Michaela Frye
      News & Views
    • EGFR is an oncogene that is frequently amplified in glioblastoma. A new study suggests a tumour-suppressive role of EGFR in EGFR-amplified glioblastoma regulated by ligand abundance. Increased EGFR ligand in EGFR-amplified glioblastoma suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.

      • Mary Clare Beytagh
      • William A. Weiss
      News & Views
    • Imaging technologies drive discovery in cell biology. Innovations in microscopy hardware, imaging methods and computational analysis of large-scale, complex datasets can increase imaging resolution, definition and allow access to new biology. We asked experts at the leading edge of biological imaging what they are most excited about when it comes to microscopy in cell biology and what challenges need to be overcome to reach these goals.

      • Brenda Andrews
      • Jae-Byum Chang
      • Assaf Zaritsky
  • After earning a PhD in Molecular Systems Biology from ETH Zurich and studying cancer metabolism as a postdoctoral fellow at MIT, Sarah-Maria Fendt started an independent research group in 2013 in a joint appointment at the Flemish Institute for Biotechnology (VIB) and the University of Leuven (KU Leuven) in Belgium.

    • Sarah-Maria Fendt
    Turning Points
  • Pride holds a special place in the hearts of lesbian, gay, bisexual, transgender, queer, intersex, asexual+ (LGBTQIA+) individuals as a time to celebrate the progress we have made, and advocate for the advances yet to come. Here, I highlight ways in which the scientific community has had a crucial role in driving this progress, and provide a personal perspective on the importance of being open and proud of my identity as a gay cell biologist.

    • Yee-Hung Mark Chan
    World View
Metabolic circuits

Metabolic communication across biological scales

This Collection showcases recent articles from Nature Cell Biology, Nature Metabolism and Nature Reviews Molecular Cell Biology covering cellular to systemic metabolic regulation. This selection accompanies the Nature Conference “Metabolic Communication Across Biological Scales” and provides a resource about current trends and directions in this field.


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