Volume 27 Issue 2, February 2022

Human neurons with 1q21.1 deletion or duplication are associated with developmental deficits. Cortical preplate marker T-Box Brain 1 (TBR1, green, upper panel) and deep layer marker Coup-TFI Interacting Protein 2 (CTIP2, green, lower panel) were differentially expressed in iPSC derived MAP2+ neurons (red) carrying 1q21.1 deletion (centre) or duplication (right) in comparison to non-carrier controls (left). The nuclei are stained with DAPI (blue)". For more information see the article by Chapman et al. on pages 819-830.