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Morphological plasticity of ventral pallidal astrocytes is associated with D1 receptor-expressing terminals during heroin seeking

Molecular Psychiatry volume 27, pages 771–772 (2022)Cite this article

A Correction to this article was published on 20 May 2022

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(A) Astrocytes in the dorsolateral ventral pallidum (green) were co-labeled with terminals from nucleus accumbens D1 or D2 receptor-expressing neurons (red). Imaged astrocytes (green, B) were digitally rendered (C) and their co-registration with mCherry-labeled terminals (red) and the presynaptic marker synaptojanin 1 (SYNJ1, blue) was quantified (D, white; box magnified in inset). (E) The degree of triple co-registration in D1-Cre rats was elevated during extinction training, indicating increased astroglial proximity to D1-expressing terminals (Kruskal–Wallis = 10.38 p = 0.0056, **p = 0.004 Ext v. Sal using Dunn’s test). This increase was restored to control levels during cue-induced reinstatement of heroin seeking (p > 0.9999 Sal v. Rst using Dunn’s test). No changes were detected at synapses containing D2-neuron terminals (D, Kruskal–Wallis = 1.571 p = 0.4560). (E) Data shown as median, N shown in legend as cells/animals. Sal, yoked saline; Ext, extinguished; Rst, 15 min reinstated. For more information, please refer to the article by Kruyer et al. in this issue.

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Authors and Affiliations

  1. Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA

    Anna Kruyer, Danielle Dixon, Ariana Angelis, Davide Amato & Peter W. Kalivas

  2. Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Davide Amato

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  1. Anna Kruyer
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  2. Danielle Dixon
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  3. Ariana Angelis
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  4. Davide Amato
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  5. Peter W. Kalivas
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Correspondence to Anna Kruyer.

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The original online version of this article was revised: The article “Morphological plasticity of ventral pallidal astrocytes is associated with D1 receptor-expressing terminals during heroin seeking”, written by Anna Kruyer, Danielle Dixon, Ariana Angelis, Davide Amato, Peter W. Kalivas, was originally published online on the publisher’s internet portal on 29 April 2022 with Open Access under a Creative Commons Attribution (CC BY) license 4.0 . After publication in volume 27, issue 2, page 771–772 the author(s) decided to cancel the Open Access. Therefore, the copyright of the article changed on 4 May 2022 to © The Author(s), under exclusive licence to Springer Nature Limited 2022 with all rights reserved.

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Kruyer, A., Dixon, D., Angelis, A. et al. Morphological plasticity of ventral pallidal astrocytes is associated with D1 receptor-expressing terminals during heroin seeking. Mol Psychiatry 27, 771–772 (2022). https://doi.org/10.1038/s41380-022-01560-4

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