Focus
Ten Year Anniversary Special
- Focus issue:
- Oct 2014 Volume 11, No 10
Nature Methods is ten years old. In this anniversary issue, we highlight our choice of the ten areas of methods development with the most impact on biological research over the past decade, and feature commentaries on a subset of these methods.
Visit Methagora to browse Nature Methods papers in these areas.
Editorial
Ten Year Anniversary Special
Ten years of Methods - p973
doi:10.1038/nmeth.3141
The decade since the launch of Nature Methods has been one of intense and dynamic development in biological research methods. We predict this will continue.
Abstract - Ten years of Methods | Full Text - Ten years of Methods | PDF (89 KB) - Ten years of Methods
Commentaries
Ten Year Anniversary Special
Ten years of Methods - pp1000 - 1001
doi:10.1038/nmeth1014-1000
Our choice, among many candidates, of the ten areas of methods development with the most impact on biological research over the last decade. Visit Methagora to browse Nature Methods papers in some of these areas.
Abstract - Ten years of Methods | Full Text - Ten years of Methods | PDF (1,473 KB) - Ten years of Methods
Ten Year Anniversary Special
A defining decade in DNA sequencing - pp1003 - 1005
John D McPherson
doi:10.1038/nmeth.3106
A revolution in DNA sequencing technology has enabled new insights from thousands of genomes sequenced across taxa.
Abstract - A defining decade in DNA sequencing | Full Text - A defining decade in DNA sequencing | PDF (3,716 KB) - A defining decade in DNA sequencing
Ten Year Anniversary Special
The fate of cell reprogramming - pp1006 - 1008
Peter Karagiannis & Shinya Yamanaka
doi:10.1038/nmeth.3109
The ability to convert somatic cells to induced pluripotent stem cells has immense potential to further our understanding of development and disease mechanisms, and for cellular therapy. Before researchers can achieve these goals, they must expand current methodology to incorporate animal models and quantitative descriptions of the essential phenomena driving reprogramming.
Abstract - The fate of cell reprogramming | Full Text - The fate of cell reprogramming | PDF (218 KB) - The fate of cell reprogramming
Ten Year Anniversary Special
Genome engineering: the next genomic revolution - pp1009 - 1011
Charles A Gersbach
doi:10.1038/nmeth.3113
A decade of advances in genome engineering technologies has enabled the editing of genome sequences much like one edits computer code; many more applications for precisely manipulating genome structure and function are on the horizon.
Abstract - Genome engineering: the next genomic revolution | Full Text - Genome engineering: the next genomic revolution | PDF (617 KB) - Genome engineering: the next genomic revolution
Ten Year Anniversary Special
Optogenetics: the age of light - pp1012 - 1014
Michael Häusser
doi:10.1038/nmeth.3111
The optogenetic revolution is transforming neuroscience. The dramatic recent progress in using light to both control and read out neural activity has highlighted the need for better probes, improved light delivery and more careful interpretation of results, which will all be required for optogenetics to fully realize its remarkable potential.
Abstract - Optogenetics: the age of light | Full Text - Optogenetics: the age of light | PDF (1,249 KB) - Optogenetics: the age of light
Ten Year Anniversary Special
Single-molecule methods leap ahead - pp1015 - 1018
Taekjip Ha
doi:10.1038/nmeth.3107
Much of our knowledge about biological systems has been obtained by examining ensembles of molecules. However, this has begun to change because of the unprecedented precision and clarity afforded by single-molecule measurements. The last decade has seen amazing advances in the resolution and complexity of these methods, making it possible to ask and answer entirely new types of biological questions.
Abstract - Single-molecule methods leap ahead | Full Text - Single-molecule methods leap ahead | PDF (432 KB) - Single-molecule methods leap ahead