This study describes benchmarking and validation of computational tools for detecting circRNAs, finding most to be highly precise with variations in sensitivity and total detection. The study also finds over 315,000 putative human circRNAs.

Diversity in human neuroscience studies is an important and recurring topic of discussion. Though slow, progress is being made.

To study soil with a view to ecosystems, researchers iterate between experiments in the lab, the field and controlled environments.

Originally from central Mexico and now found worldwide, the axolotl is a prominent model organism in numerous fields of research.

This article describes a time-resolved cryo-plunger that combines a droplet-based microfluidic mixer with a laser-induced generator of microjets that allows rapid reaction initiation and plunge-freezing of cryo-EM grids. A time resolution of 5 ms was achieved using this approach.

Gaussian Process Spatial Alignment (GPSA) aligns multiple spatially resolved genomics and histology datasets and improves downstream analysis.

Compared to other sequences, extra-long tandem repeats, such as centromeres and immunoglobulin loci, are more difficult to align. This study presents UniAligner, a computational method for efficiently and accurately aligning extra-long tandem repeats, facilitating analysis of their variation and evolution.

contrastiveVI separates single-cell gene expression variations uniquely related to treatment conditions from those shared with control conditions using a probabilistic latent variable model.

Using a deep generative model, CellBender models and denoises droplet-based single-cell data and improves multiple downstream analyses.

By probabilistic modeling of gene regulation and expression kinetics, Dictys infers dynamic and context-specific gene regulatory networks using single-cell multiomics data.

Nature uses only the longest threads to weave her patterns, so that each small piece of her fabric reveals the organization of the entire tapestry. —Richard Feynman

Originally from central Mexico and now found worldwide, the axolotl is a prominent model organism in numerous fields of research.