Collection | 08 January 2019

Bioelectronic devices

Implantable sensors and electrodes that take advantage of new materials, device designs and fabrication strategies enable new and improved biomedical applications.

This Collection is updated when relevant new content is published. Content appears in reverse chronological order. See all Collections from Nature Biomedical Engineering.

Research

Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces

Customized soft electrode arrays that are well adjusted to specific anatomical environments, functions and experimental models can be rapidly prototyped via the robotically controlled deposition of conductive inks and insulating inks.

Dzmitry Afanasenkau,
Daria Kalinina ⋯
Pavel Musienko

Article | 21 Sep 2020 | Nature Biomedical Engineering

Decoding of facial strains via conformable piezoelectric interfaces

An integrated system consisting of conformable piezoelectric devices, three-dimensional digital image correlation, multiphysics modelling and real-time classification algorithms predicts facial kinematics and decodes facial deformations.

Tao Sun,
Farita Tasnim ⋯
Canan Dagdeviren

Article | 22 Oct 2020 | Nature Biomedical Engineering

Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery

Soft multilayer electronic arrays on endocardial balloon catheters allow for multiplexed high-density spatiotemporal sensing and actuation, as shown in perfused ex vivo hearts.

Mengdi Han,
Lin Chen ⋯
John A. Rogers

Article | 7 Sep 2020 | Nature Biomedical Engineering

Mechano-acoustic sensing of physiological processes and body motions via a soft wireless device placed at the suprasternal notch

A wireless device designed to be conformally placed on the suprasternal notch can continuously provide real-time information of essential vital signs as well as talking time, swallow counts and sleep patterns.

KunHyuck Lee,
Xiaoyue Ni ⋯
John A. Rogers

Article | 25 Nov 2019 | Nature Biomedical Engineering

Functionalized helical fibre bundles of carbon nanotubes as electrochemical sensors for long-term in vivo monitoring of multiple disease biomarkers

Functionalized multi-walled carbon nanotubes twisted into helical fibre bundles that mimic the hierarchical structure of muscle can be used for the long-term monitoring of multiple disease biomarkers in vivo.

Liyuan Wang,
Songlin Xie ⋯
Huisheng Peng

Article | 28 Oct 2019 | Nature Biomedical Engineering

A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons

An electronic interface with 4,096 electrodes can intracellularly record postsynaptic potentials and action potentials from thousands of connected mammalian neurons in vitro.

Jeffrey Abbott,
Tianyang Ye ⋯
Donhee Ham

Article | 23 Sep 2019 | Nature Biomedical Engineering

Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring

Body-scale epidermal electronic interfaces for electrophysiological recordings enable the control of a transhumeral prosthesis, long-term electroencephalography, and simultaneous electroencephalography and structural and functional MRI.

Limei Tian,
Benjamin Zimmerman ⋯
John A. Rogers

Article | 18 Feb 2019 | Nature Biomedical Engineering

Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow

A battery-free implantable pressure sensor made entirely of biodegradable materials and based on fringe-field capacitor technology can wirelessly measure arterial blood flow in live rats.

Clementine M. Boutry,
Levent Beker ⋯
Zhenan Bao

Article | 8 Jan 2019 | Nature Biomedical Engineering

Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation

Conductive and elastic hydrogel-based microelectronic arrays with high current-injection density and low interfacial impedance with tissue enable the localized low-voltage electrical stimulation of the sciatic nerve in live mice.

Yuxin Liu,
Jia Liu ⋯
Zhenan Bao

Article | 8 Jan 2019 | Nature Biomedical Engineering

A wireless and artefact-free 128-channel neuromodulation device for closed-loop stimulation and recording in non-human primates

A closed-loop and wireless 128-channel neuromodulation device enables electrical stimulation as well as artefact-free long-term recording of local field potentials in the brain of an untethered non-human primate.

Andy Zhou,
Samantha R. Santacruz ⋯
Rikky Muller

Article | 31 Dec 2018 | Nature Biomedical Engineering

Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging

Implantable inductively coupled resonant circuits that change their properties in response to electrical or photonic cues and are detectable in magnetic resonance imaging enable the remote sensing of bioluminescence in rodent brains.

Aviad Hai,
Virginia Ch. Spanoudaki ⋯
Alan Jasanoff

Article | 22 Oct 2018 | Nature Biomedical Engineering

Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

Bioresorbable pressure sensors with significantly improved operational lifetimes, as exemplified via the monitoring of intracranial pressure in rats for over 25 days, can be similarly accurate to analogous non-resorbable clinical devices.

Jiho Shin,
Ying Yan ⋯
John A. Rogers

Article | 1 Oct 2018 | Nature Biomedical Engineering

Monitoring of the central blood pressure waveform via a conformal ultrasonic device

An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.

Chonghe Wang,
Xiaoshi Li ⋯
Sheng Xu

Article | 11 Sep 2018 | Nature Biomedical Engineering

Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

An implantable, wirelessly powered optoelectronic device that adheres to tissue for the delivery of low-dose, long-term photodynamic therapy leads to significant antitumour effects in mice with intradermally transplanted tumours.

Kento Yamagishi,
Izumi Kirino ⋯
Toshinori Fujie

Article | 16 Jul 2018 | Nature Biomedical Engineering

Localization of microscale devices in vivo using addressable transmitters operated as magnetic spins

The location of microdevices in the body of anaesthetized mice can be retrieved with sub-millimetre precision by adopting principles from nuclear magnetic resonance.

Manuel Monge,
Audrey Lee-Gosselin ⋯
Azita Emami

Article | 12 Sep 2017 | Nature Biomedical Engineering

Flexible piezoelectric devices for gastrointestinal motility sensing

An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

Canan Dagdeviren,
Farhad Javid ⋯
Giovanni Traverso

Article | 10 Oct 2017 | Nature Biomedical Engineering

Prolonged energy harvesting for ingestible devices

A biocompatible, energy-harvesting electrochemical cell delivers power to a wireless sensor for an average of 6.1 days of temperature measurements in the gastrointestinal tract of pigs.

Phillip Nadeau,
Dina El-Damak ⋯
Giovanni Traverso

Article | 6 Feb 2017 | Nature Biomedical Engineering

Conformal phased surfaces for wireless powering of bioelectronic microdevices

A phased electromagnetic surface that conforms to the body surface can regulate cardiac rhythm in a porcine model through the wireless transmission of power to miniaturized semiconductor devices implanted at depths of over 4 cm.

Devansh R. Agrawal,
Yuji Tanabe ⋯
John S. Ho

Article | 6 Mar 2017 | Nature Biomedical Engineering

Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology

Capacitive coupling between tissue and flexible integrated electronics through a sealing dielectric layer facilitates long-term electrophysiology measurements, as demonstrated in ex vivo Langendorff heart models.

Hui Fang,
Ki Jun Yu ⋯
John A. Rogers

Article | 1 Mar 2017 | Nature Biomedical Engineering

News & Comment

Poking neurons and nerves precisely

The integration and miniaturization of components in electronic and photonic devices for interfacing with neural tissue allow for ever more precise neural recording and stimulation.

Editorial | 19 Feb 2020 | Nature Biomedical Engineering

Soft and fibrous multiplexed biosensors

Functionalized flexible helical bundles of carbon nanotubes serve as electrochemical sensors for long-term in vivo monitoring of disease biomarkers.

Ron Feiner &
Tal Dvir

News & Views | 12 Feb 2020 | Nature Biomedical Engineering

Selective activation of the visual cortex

An electrode array implanted into the optic nerve of rabbits selectively activates discrete regions of the primary visual cortex.

Shelley I. Fried &
Mohit N. Shivdasani

News & Views | 12 Feb 2020 | Nature Biomedical Engineering

Epidermal electrophysiology at scale

Large-area electrode arrays for epidermal electrophysiology offer new possibilities for the control of prosthetic devices and the monitoring of brain function.

Damiano G. Barone &
George G. Malliaras

News & Views | 7 Mar 2019 | Nature Biomedical Engineering

Fitter in-body bioelectronics

Implantable sensors and electrodes that take advantage of new materials, device designs and fabrication strategies enable new and improved biomedical applications.

Editorial | 8 Jan 2019 | Nature Biomedical Engineering

A biodegradable wireless blood-flow sensor

A soft implant wirelessly senses arterial blood flow post-surgery before being gradually resorbed.

Krishna Yeshwant &
Roozbeh Ghaffari

News & Views | 8 Jan 2019 | Nature Biomedical Engineering

Elastic and conductive hydrogel electrodes

Stretchable conductive hydrogels make microelectrode arrays that better interface with tissue.

Rylie Green

News & Views | 8 Jan 2019 | Nature Biomedical Engineering

Wireless metronomic photodynamic therapy

A wirelessly powered optoelectronic device that adheres to internal tissue facilitates the application of low-dose, long-term photodynamic cancer therapy.

Youngsik Lee &
Dae-Hyeong Kim

News & Views | 8 Jan 2019 | Nature Biomedical Engineering

Artefact-free wireless closed-loop device

A miniaturized 128-electrode brain implant enables wireless closed-loop neuromodulation with artefact cancellation in a non-human primate.

Chia-Han Chiang &
Jonathan Viventi

News & Views | 8 Jan 2019 | Nature Biomedical Engineering

Biophysical sensing in deep tissue via MRI

A microdevice implanted in deep tissue can measure electromagnetic signals and convert them to magnetic-resonance-imaging-detectable signals.

Zhijie Zhu,
Ghazaleh Haghiashtiani &
Michael C. McAlpine

News & Views | 8 Jan 2019 | Nature Biomedical Engineering

A skin patch for sensing blood pressures

A wearable ultrasound patch enables the continuous monitoring of cardiovascular performance outside the intensive care unit.

Steven R. Steinhubl &
Eric J. Topol

News & Views | 11 Sep 2018 | Nature Biomedical Engineering

Transmitting location

Microchips embedding a magnetic sensor and a radiofrequency transmitter can be localized in the body of a mouse at submillimetre resolution when under a magnetic field.

Yong Lin Kong &
Giovanni Traverso

News & Views | 12 Sep 2017 | Nature Biomedical Engineering

Sensing gastrointestinal motility

Flexible piezoelectric sensors can detect mechanical deformations in the gastrointestinal tract of ambulating pigs and simultaneously harvest energy from it.

Ghazaleh Haghiashtiani &
Michael C. McAlpine

News & Views | 10 Oct 2017 | Nature Biomedical Engineering

Bioelectronic devices: Gut-powered ingestible biosensors

A biosensing device that harvests energy from fluids in the gut is able to wirelessly transmit measurements from the gastrointestinal tract of pigs for over six days.

Arianna Menciassi

News & Views | 9 Mar 2017 | Nature Biomedical Engineering

Bioelectronic devices: Wirelessly powered implants

Phased-array antennas that conform to body surfaces efficiently transfer electromagnetic energy to miniaturized semiconductor devices implanted in pigs.

Jordan Thimot &
Kenneth L. Shepard

News & Views | 9 Mar 2017 | Nature Biomedical Engineering

Bioelectronic devices: Long-lived recordings

A silicon dioxide passivation layer dramatically lengthens the operational lifetime of flexible electronic arrays for cardiac electrophysiology.

Menahem Y. Rotenberg &
Bozhi Tian

News & Views | 9 Mar 2017 | Nature Biomedical Engineering

The quest for miniaturized soft bioelectronic devices

Soft integrated electronics packaged with miniaturized modules for wireless power and data transfer are opening up new opportunities for long-term health monitoring and therapy.

Jaemin Kim,
Roozbeh Ghaffari &
Dae-Hyeong Kim

Comment | 9 Mar 2017 | Nature Biomedical Engineering

Durable miniaturized bioelectronics

Advances in materials science and engineering enable ever-smaller and more reliable bioelectronic devices.

Editorial | 9 Mar 2017 | Nature Biomedical Engineering

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