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NEUROMODULATION

Artefact-free wireless closed-loop device

Nature Biomedical Engineering volume 3, pages 3–4 (2019)Cite this article

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A miniaturized 128-electrode brain implant enables wireless closed-loop neuromodulation with artefact cancellation in a non-human primate.

The majority of neuromodulation systems for the treatment of neurological disorders essentially operate as open-loop devices, stimulating the brain continuously by using fixed parameters that are updated periodically and manually by a clinician. Adding neural recording to these devices would enable closed-loop neuromodulation (that is, the delivery of stimulation only when it is required, according to the state of the brain) for the treatment of neurological disorders. This would improve battery life and, more importantly, could dramatically improve the effectiveness of the treatment and reduce side effects1,2. However, closed-loop neuromodulation remains challenging to implement because sensing neural signals requires sensitivity to signals as small as a few microvolts, in the presence of stimulation artefacts that can be as large as a few volts (a difference of six orders of magnitude).

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Fig. 1: Artefact-free closed-loop neuromodulation.

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  1. Department of Biomedical Engineering, Duke University, Durham, NC, USA

    Chia-Han Chiang & Jonathan Viventi

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  1. Chia-Han Chiang
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  2. Jonathan Viventi
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Correspondence to Jonathan Viventi.

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The authors declare no competing interests.

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Chiang, CH., Viventi, J. Artefact-free wireless closed-loop device. Nat Biomed Eng 3, 3–4 (2019). https://doi.org/10.1038/s41551-018-0340-9

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  • DOI: https://doi.org/10.1038/s41551-018-0340-9

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