Microscopy articles within Nature Photonics

Featured

  • Review Article |

    The ability to dynamically image features deep within living organisms, permitting real-time analysis of cellular structure and function, is important for biological science. This Review article discusses multiphoton microscopy capable of such analysis, along with technologies that are pushing the limits of phenomena that can be quantitatively imaged.

    • Erich E. Hoover
    •  & Jeff A. Squier

  • Letter |

    A parallel implementation of multifocal multiphoton modulation microscopy allows simultaneous phosphorescent lifetime and intensity imaging in vivo at speeds 100 times faster than conventional configurations. Three-dimensional imaging of a phosphorescent quenching dye is also presented.

    • Scott S. Howard
    • , Adam Straub
    •  & Chris Xu

  • News & Views |

    Researchers at Osaka University in Japan have developed a hyperspectral stimulated Raman microscope that can image the chemical bonds in living tissues at video rates.

    • Hervé Rigneault
    •  & Esben Andresen

  • Letter |

    By illuminating a sample with several uncontrolled random speckles and implementing a blind structured illumination microscopy algorithm, researchers demonstrate that image reconstruction can be achieved without knowing the original illumination pattern, at a resolution two times better than that of conventional wide-field microscopy.

    • E. Mudry
    • , K. Belkebir
    •  & A. Sentenac

  • Letter |

    By combining high-resolution nonlinear optical microscopy with few-cycle time resolution, scientists show that they are able to probe the spatiotemporal localization of light waves in random dielectric nanostructures. The findings will aid the study of light localization dynamics in a variety of passive and active random media.

    • Manfred Mascheck
    • , Slawa Schmidt
    •  & Christoph Lienau

  • News & Views |

    Using extremely broadband ultrafast near-infrared pulses, scientists have demonstrated simultaneous second-harmonic-generation, third-harmonic-generation and four-wave-mixing microscopy, enabling a range of different structures and functional groups in a biological sample to be imaged at once.

    • Brett Pearson
    •  & Thomas Weinacht

  • Letter |

    Researchers demonstrate a scheme that combines the high spatial resolution of full-field transmission X-ray microscopy (TXM) with high-spectral-resolution near-edge X-ray absorption fine structure (NEXAFS). The idea could lead to a wide range of new material studies that combine high-resolution spectroscopic techniques with nanoscale tomographic imaging.

    • Peter Guttmann
    • , Carla Bittencourt
    •  & Gerd Schneider

  • News & Views |

    By combining the benefits of multidimensional spectroscopy with photoemission electron microscopy, scientists in Germany have successfully mapped the coherence lifetimes of plasmons in silver with nanoscale spatial resolution and femtosecond temporal resolution.

    • Anders Mikkelsen

  • News & Views |

    It has long been thought that the detection of individual molecules in ambient conditions via their absorption signature was out of reach. Now, three independent research groups have developed three different methods that allow such a feat.

    • Johan Hofkens
    •  & Maarten B. J. Roeffaers

  • Letter |

    The diffraction of light scales with wavelength, thereby placing fundamental limits on applications such as imaging, microscopy and communications. Here, researchers experimentally demonstrate scale-free propagation in supercooled structures and cancel diffraction, instead of merely compensating for it, as is the case for most approaches in nonlinear optics.

    • E. DelRe
    • , E. Spinozzi
    •  & C. Conti

  • Interview |

    Imaging the transient carrier dynamics in semiconductors at both high temporal and spatial resolution has long been a goal for solid-state scientists. Hidemi Shigekawa from the University of Tsukuba in Japan told Nature Photonics how his team accomplished this feat.

    • Rachel Won

  • News & Views |

    Exploiting the self-healing properties of Bessel beams, scientists demonstrate a microscope that offers better image quality and deeper penetration in dense media than current imaging schemes.

    • Miles Padgett

  • Article |

    A prototype microscope built with self-reconstructing Bessel beams is shown to be able to reduce scattering artifacts as well as increase image quality and penetration depth in three-dimensional inhomogeneous opaque media.

    • Florian O. Fahrbach
    • , Philipp Simon
    •  & Alexander Rohrbach

  • Article |

    Distortions in a propagating optical wavefront — known as aberrations — prevent the achievement of a diffraction-limited beam spot. A generic in situ wavefront correction method based on complex modulation is demonstrated, allowing compensation for all aberrations along the whole optical train. The scheme is used for direct trapping through highly turbid and diffusive media, opening up new applications for optical micromanipulation in colloidal and biological physics.

    • Tomáš Čižmár
    • , Michael Mazilu
    •  & Kishan Dholakia

  • News & Views |

    The development of new light sources and focusing techniques suggests that ultrafast X-ray microscopy is poised to impact numerous fields of science.

    • David Pile

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