Featured
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News & Views |
Sub-cycle photonics in correlated materials
Sub-cycle confinement and control of phase transitions in strongly correlated materials are theoretically demonstrated, potentially providing a way to investigate electron dynamics on timescales previously unattainable with these materials.
- Eleftherios Goulielmakis
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Article |
Mid-infrared wide-field nanoscopy
Wide-field mid-infrared photothermal imaging is developed to supress the resolution degradation caused by photo-thermal heat diffusion. By employing a single-objective synthetic-aperture imaging with synchronized subnanosecond mid-infrared and visible light sources, spatial resolution of 120 nm is obtained.
- Miu Tamamitsu
- , Keiichiro Toda
- & Takuro Ideguchi
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News & Views |
Illuminating cancer with sonoafterglow
Ultrasound-induced luminescence in trianthracene derivative-based nanoparticles enables tumour imaging and immunological profiling in a variety of in vivo models.
- Cheng Xu
- & Kanyi Pu
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News & Views |
Single protein imaging with holography
A non-common-path interferometric scheme enables holographic detection of single proteins of mass 90 kDa and estimation of single-protein polarizability.
- Chia-Lung Hsieh
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Article
| Open AccessSingle-protein optical holography
Holographic microscopy with independent control of the signal and reference fields enables the holographic imaging of a single protein with mass below 100 kDa and estimation of their polarizability.
- Jan Christoph Thiele
- , Emanuel Pfitzner
- & Philipp Kukura
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News & Views |
Mechanical anisotropy with Brillouin spectroscopy in one shot
Brillouin light scattering anisotropy microscopy affords single-shot collection of angle-resolved phonon dispersion, enabling the mapping of mechanical anisotropies in living matter with a frequency resolution of 10 MHz and a spatial resolution of 2 µm.
- Yogeshwari S. Ambekar
- & Giuliano Scarcelli
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Article |
In vivo ultrasound-induced luminescence molecular imaging
Ultrasound-induced luminescence enables in vivo molecular imaging of tumours and lymph nodes with spatial resolution of 1.46 mm.
- Youjuan Wang
- , Zhigao Yi
- & Weihong Tan
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News & Views |
Brighter organic scintillators by hot exciton manipulation
The fast response and efficiency of plastic scintillators are severely degraded by the preferential population of slow triplet excited states in luminescence centres, such as in dye molecules. This issue can be solved by hot exciton manipulation, which avoids population of the lowest triplet state.
- Martin Nikl
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Article |
Optical readout of the chemical potential of two-dimensional electrons
An optical readout technique for the chemical potential of an arbitrary two-dimensional material is realized using a monolayer transition metal dichalcogenide semiconductor sensor whose optical response sharply depends on the chemical potential.
- Zhengchao Xia
- , Yihang Zeng
- & Kin Fai Mak
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Article |
A wireless optoelectronic probe to monitor oxygenation in deep brain tissue
A wireless optoelectronic probe integrates a microscale light-emitting diode and a photodetector coated with oxygen-sensitive dyes to monitor the partial pressure of oxygen in the deep brain of freely moving mice.
- Xue Cai
- , Haijian Zhang
- & Xing Sheng
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Article |
Brillouin light scattering anisotropy microscopy for imaging the viscoelastic anisotropy in living cells
Single-shot angle-resolved Brillouin light scattering microscopy enables spatiotemporal mapping of mechanical anisotropy in living cells with a spatial resolution below 2 µm and precision in the Brillouin frequency shift of 10 MHz.
- Hamid Keshmiri
- , Domagoj Cikes
- & Kareem Elsayad
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Article
| Open AccessGenerating free-space structured light with programmable integrated photonics
Using programmable integrated photonics to generate a higher-order free-space structured light beam promises lossless and reconfigurable control of the spatial distribution of light’s amplitude and phase with very short switching times.
- Johannes Bütow
- , Jörg S. Eismann
- & Peter Banzer
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Article |
Efficient and ultrafast organic scintillators by hot exciton manipulation
Researchers overcome the typical scintillator trade-off between high efficiency and speed. In organic scintillators, researchers drove hot excitons into fast singlet emission states without involving the lowest triplet states, which led to a fast radiative lifetime and strong light yield that may be applicable to ultrafast detection and imaging.
- Xinyuan Du
- , Shan Zhao
- & Jiang Tang
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Article
| Open AccessPlasmonic photoconductive terahertz focal-plane array with pixel super-resolution
A terahertz focal-plane array based on a two-dimensional array of plasmonic photoconductive nanoantennas offers high-quality imaging in the terahertz region.
- Xurong Li
- , Deniz Mengu
- & Mona Jarrahi
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News & Views |
Ambient microwave-to-optical converter
A coherent microwave-to-optical conversion scheme, previously feasible only under cryogenic environments, has now been expanded to ambient conditions by using Rydberg atoms.
- Kai-Yu Liao
- , Hui Yan
- & Shi-Liang Zhu
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Review Article |
Label-free biomedical optical imaging
This Review covers a comparison between various label-free biomedical imaging techniques, their advantages over label-based methods and relevant applications.
- Natan T. Shaked
- , Stephen A. Boppart
- & Jürgen Popp
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News & Views |
Listening to microorganisms with light
Combining photoacoustic excitation with optomechanics enables the mechanical modes associated with entire microorganisms to be detected, demonstrating that mechanical spectroscopy allows us to identify microorganisms and characterize their life stages.
- Eduardo Gil-Santos
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News & Views |
Event-based super-resolution microscopy
Event-based detectors, which respond to local changes in light intensity rather than producing images, enable super-resolution single-molecule localization microscopy with sensitivity and resolution comparable to conventional methods.
- Ian M. Dobbie
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Article |
Event-based vision sensor for fast and dense single-molecule localization microscopy
Event-based sensors enable super-resolution single-molecule localization microscopy with comparable quality and resolution to traditional scientific cameras, while also overcoming the limitations of high-density imaging.
- Clément Cabriel
- , Tual Monfort
- & Ignacio Izeddin
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Article
| Open AccessContinuous wideband microwave-to-optical converter based on room-temperature Rydberg atoms
Continuous-wave conversion of a 13.9 GHz field to a near-infrared optical signal is demonstrated by using Rydberg atoms at room temperature. The conversion bandwidth is 16 MHz and the conversion dynamic range is 57 dB, descending down to 3.8 K noise-equivalent temperature.
- Sebastian Borówka
- , Uliana Pylypenko
- & Michał Parniak
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Article
| Open AccessAcousto-optic modulation of gigawatt-scale laser pulses in ambient air
Air-based acousto-optic modulation is shown to be able to efficiently control gigawatt-scale, ultrashort laser pulses.
- Yannick Schrödel
- , Claas Hartmann
- & Christoph M. Heyl
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News & Views |
Turning single molecule vibrations into visible light
Vibrations of individual molecules are difficult to detect due to thermal noise. In a recent report, researchers overcome this challenge, upconverting mid-infrared photons into visible light using nanophotonic cavities. The result is high-efficiency optical readout for single-molecule vibrational spectroscopy.
- Matthew Sheldon
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Article |
Wide-field coherent anti-Stokes Raman scattering microscopy using random illuminations
Combining random illumination microscopy with coherent anti-Stokes Raman scattering and sum-frequency generation contrasts, a robust wide-field nonlinear microscope with a 3 µm axial sectioning capability and a 300 nm transverse resolution is demonstrated.
- Eric M. Fantuzzi
- , Sandro Heuke
- & Hervé Rigneault
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News & Views |
Deconvolution enhances fluctuation detection
The introduction of a two-step deconvolution workflow maximizes the detection of fluorescence in fluctuation-based super-resolution imaging, enabling a square millimetre field of view to be captured in as little as ten minutes.
- David Baddeley
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News & Views |
Attosecond movies of nano-optical fields
A transmission electron microscopy technique enables movies of optical near-fields to be recorded with a temporal resolution faster than the oscillation of optical electric fields.
- Yuya Morimoto
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News & Views |
Lithography-free reconfigurable photonic processor
A lithography-free photonic processor through dynamic control of optical gain distributions is demonstrated, allowing reconfigurable photonic neural networks and more efficient signal processing, and showing great promise in easing data traffic as well as accelerating information processing speeds.
- Anna P. Ovvyan
- & Wolfram H. P. Pernice
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Article |
Single-particle photoacoustic vibrational spectroscopy using optical microresonators
Natural vibrations of mesoscopic particles, such as living cells, are typically faint; occurring at megahertz to gigahertz frequencies also makes detection challenging. Now, researchers demonstrate real-time measurement of natural vibrations of single mesoscopic particles by using photoacoustic excitation and acoustic coupling to an optical microresonator for readout.
- Shui-Jing Tang
- , Mingjie Zhang
- & Yun-Feng Xiao
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Article |
Phase conjugation with spatially incoherent light in complex media
The non-invasive control of light based on incoherent emission from multiple target positions can be achieved by retrieving mutually incoherent scattered fields from speckle patterns, and then time-reversing scattered fluorescence with digital phase conjugation.
- YoonSeok Baek
- , Hilton B. de Aguiar
- & Sylvain Gigan
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Article |
Chaotic microcomb-based parallel ranging
The intrinsic random amplitude and phase modulation of 40 distinct lines of a microresonator frequency comb operated in the modulation instability regime are used to realize massively parallel random-modulation continuous-wave light detection and ranging, without requiring any electro-optical modulator or microwave synthesizer.
- Anton Lukashchuk
- , Johann Riemensberger
- & Tobias J. Kippenberg
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Article
| Open AccessSingle multimode fibre for in vivo light-field-encoded endoscopic imaging
Spatial-frequency tracking adaptive beacon light-field encoded endoscopy enables imaging through a single multimode fibre under bending and twisting. In vivo imaging with subcellular resolution is demonstrated in mice models.
- Zhong Wen
- , Zhenyu Dong
- & Qing Yang
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Article
| Open AccessPhotonic radar for contactless vital sign detection
Photonic radar is exploited for non-contact vital sign detection with a demonstration on a cane toad with a view to application in humans. Optical signals generated from the system are also explored for LiDAR-based vital sign detection, which may yield improved accuracy and system robustness.
- Ziqian Zhang
- , Yang Liu
- & Benjamin J. Eggleton
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Article |
Bond-selective fluorescence imaging with single-molecule sensitivity
Two-photon excitation with mid- and near-infrared pulses encodes bond selectivity in fluorescence imaging. Single-molecule imaging and spectroscopy is demonstrated on individual fluorophores as well as various labelled biological targets.
- Haomin Wang
- , Dongkwan Lee
- & Lu Wei
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News & Views |
Tracking nanoscopic motion with minima of light
Two papers in Science demonstrate tracking of the stepping motion of the kinesin motor protein with nanometric spatial precision and sub-millisecond temporal resolution by using MINFLUX, a highly photon-efficient single-molecule localization technique.
- Fernando D. Stefani
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Article |
Enhanced detection of fluorescence fluctuations for high-throughput super-resolution imaging
Super-resolution imaging based on autocorrelation with two-step deconvolution (SACD) enables recording super-resolution images with 128-nm spatial resolution over a field of view of 2.0 mm × 1.4 mm within a 10-min acquisition time.
- Weisong Zhao
- , Shiqun Zhao
- & Haoyu Li
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Article |
Unidirectional unpolarized luminescence emission via vortex excitation
The use of a nanopillar lattice and orbital angular momentum provides control over the directionality of light emission on the nanoscale.
- Jincheng Ni
- , Shengyun Ji
- & Cheng-Wei Qiu
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Article |
Broadband control of topological–spectral correlations in space–time beams
Introduction of a diffractive axicon in a pulse shaper enables imparting topological–spectral correlation to ultrafast pulses over 200 nm in the visible region and with topological charges up to 80.
- Marco Piccardo
- , Michael de Oliveira
- & Antonio Ambrosio
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Correspondence |
Open-source tools enable accessible and advanced image scanning microscopy data analysis
- Alessandro Zunino
- , Eli Slenders
- & Giuseppe Vicidomini
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Article |
Lithography-free reconfigurable integrated photonic processor
Spatial light modulator-based lithography-free programmable light transmission through optical gain medium is demonstrated for optical switching and a rudimentary photonic neural network.
- Tianwei Wu
- , Marco Menarini
- & Liang Feng
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Article |
A double-tapered fibre array for pixel-dense gamma-ray imaging
Researchers engineer double-tapered optical-fibre arrays and use perovskite nanocrystal substrates for X-ray imaging with a three orders of magnitude output gain and spatial resolution of 22 lp mm−1. Arrayed gamma-ray imaging is also demonstrated using a nanocrystal scintillator film.
- Luying Yi
- , Bo Hou
- & Xiaogang Liu
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Article |
Entanglement-enhanced optomechanical sensing
Joint force measurements with entangled optical probes on two optomechanical sensors are demonstrated. The force sensitivity is improved by 40% in the shot-noise-dominant regime. The sensing bandwidth is improved by 20% in the thermal noise limit.
- Yi Xia
- , Aman R. Agrawal
- & Zheshen Zhang
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News & Views |
Super-resolution photothermal microscopy
A photothermal microscopy technique overcomes the diffraction limit by exploiting the spatiotemporal dynamics of heat dissipation within the imaging volume, offering new opportunities for super-resolution, bond-selective and label-free imaging of biological targets.
- Zhilun Zhao
- & Wei Min
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Article |
Direct characterization of shear phonons in layered materials by mechano-Raman spectroscopy
Mechano-Raman spectroscopy is demonstrated by using interlayer phonons of atomic-layer vibrators to drive synchronous motion of the metallic plasmonic structure that can then be detected. The modulated light scattering brings out the information that cannot be accessed by optical Raman spectroscopy.
- Susu Fang
- , Sai Duan
- & Weigao Xu
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Article |
Image sensing with multilayer nonlinear optical neural networks
A nonlinear optical neural network image sensor based on an image intensifier enables efficient all-optical image encoding for a variety of machine-vision tasks.
- Tianyu Wang
- , Mandar M. Sohoni
- & Peter L. McMahon
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Article |
Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per second
3D-RAPID, a scalable computational microscope using 54 cameras, records 3D topographic videos of freely moving organisms over an area of 135 cm2 at a spatial resolution of tens of micrometres and at a throughput exceeding 5 gigapixels per second.
- Kevin C. Zhou
- , Mark Harfouche
- & Roarke Horstmeyer
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Article |
Super-resolution imaging of non-fluorescent molecules by photothermal relaxation localization microscopy
Photothermal relaxation localization microscopy allows super-resolution imaging of non-fluorescent targets by leveraging spatial-dependent heat dissipation in photothermal microscopy. Individual lipid droplets and their distribution in living cells are imaged at spatial resolutions down to 120 nm.
- Pengcheng Fu
- , Wanlin Cao
- & Delong Zhang
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Letter
| Open AccessVideo-rate hyperspectral camera based on a CMOS-compatible random array of Fabry–Pérot filters
A hyperspectral camera based on a random array of CMOS-compatible Fabry–Pérot filters is demonstrated. The hyperspectral camera exhibits performance comparable with that of a typical RGB camera, with 45% sensitivity to visible light, a spatial resolution of 3 px for 3 dB contrast, and a frame rate of 32.3 fps at VGA resolution.
- Motoki Yako
- , Yoshikazu Yamaoka
- & Atsushi Ishikawa